Preventive intervention of dental caries Calcium fluoride Dental caries Dental plaque Fluoride varnish Remineralization
Conditions
Interventions
After fluoride application, subjects are allowed to drink 240 ml of water and eat soft food at 5 minutes post-varnish application. Then, they can eat hard food and brush their teeth at 4 hours. This g
Standard,FV-NPO,Avoid brushing
Sponsors
Chulalongkorn University
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Healthy, 2. Not less than 5 teeth present in any dental quadrant (At least 20 permanent teeth), 3. Normal oral health status (No evidence of active caries or periodontal disease), 4. Normal salivary flow (unstimulated saliva 0.3 - 0.6 ml/min), 5. Brushing with fluoride toothpaste 2 times a day everyday
Exclusion criteria
Exclusion criteria: 1. Use of medical conditions that reduced salivary flow, 2. History of fluoride allergy or hypersensitivity to colophony (Natural rosin), 3. Ulcerative gingivitis or stomatitis, 4. Bronchial asthma, 5. History of fluoride supplement use apart from fluoride toothpaste within 1 year, 6. Drinking habit of fluoride rich products such as green tea more than 3 times a day, 7. Participants with allergies to gluten, egg, milk, nuts, soy, or shellfish
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fluoride in saliva Baseline, 15, 30, 40 minutes, 1, 2 hours, 4 hours 10 minutes, 24, 48 hours after intervention Fluoride ion specific electrode,fluoride in biofilm Baseline, 15, 30, 40 minutes, 1, 2 hours, 4 hours 10 minutes, 24, 48 hours after intervention spectrophotometer,fluoride in enamel 5 and 14 days after intervention Fluoride ion specific electrode,Lesion depth 14 days after intervention micro-CT,mineral density 14 days after intervention micro-CT | — |
Countries
Thailand
Contacts
Public ContactChonticha Jitongart
Faculty of Dentistry, Chulalongkorn university
Outcome results
None listed