Hepatocellular carcinoma who underwent conventional TACE. PES HCC Dexamethasone N-acetylcysteine liver decompensation
Conditions
Interventions
single dexamethasone 8 mg IV pre cTACE,IV N-Acetylcysteine 150 mg/mg/kg in 1st hour then 50mg/kg in 4hr then 6.25/mg/kg/hr 48 hr after cTACE
Active Comparator Drug,Active Comparator Drug
Dexamethasone,N-Acetylcysteine
Sponsors
FACULTY OF MEDICINE VAJIRA HOSPITAL foundation for research
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: age 18-70 yrs old was diagnosis of Hepatocellular carcinoma who underwent conventional TACE
Exclusion criteria
Exclusion criteria: decompensated cirrhosis congestive heart failure with or without respiration failure severe comorbidity (uncontrolled DM, HbA1C >8.5, untreated HIV infection) drug allergen to N-acetylcysteine, dexamethasone pregnancy previous use of NSIADs /steroids / N-acetylcysteine contraindication of TACE ongoing sepsis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Post embolism syndrome in 48 hr after TACE PES was defined by South West Oncology Group toxicity code grading of more than 2 that was calculated using incidence of fever, nausea, vomiting, and pain. | — |
Secondary
| Measure | Time frame |
|---|---|
| post-Trans arterial chemoembolization liver decompensation in 48 hr after TACE liver decompensation,ALBI change 0 ,2,28day Alb , TB | — |
Countries
Thailand
Contacts
Public Contactpreeyamas koonsiripaiboon
hospital
Outcome results
None listed