male or female patients aged 18-25 years with moderate to severe acne vulgaris acne, isotretinoin, fish oil, mucocutaneous side effects
Conditions
Interventions
the group receiving fish oil: take 1 capsule of fish oil and 1 soft capsule of 10 mg isotretinoin after meal once daily for 3 months ,the group receiving placebo: take 1 capsule of placebo and 1 soft
fish oil (study product),placebo
Sponsors
Ratchadapiseksompotch Fund Chulalongkorn university
Eligibility
Sex/Gender
All
Age
18 Years to 25 Years
Inclusion criteria
Inclusion criteria: 1. male or female, aged 18-25 years, diagnosed with moderate to severe acne vulgaris 2. BMI < 29.9 3. ability to follow research protocols
Exclusion criteria
Exclusion criteria: 1. Individuals with a history of used topical treatment for acne vulgaris within a past month 2. Those who have documented allergy to isotretinoin 3. individuals with a history of taking fish oil supplements within the past 3 months 4. Those who have undergone procedures or treatments for acne with any options 5. individuals with diseases associated with acne, such as PCOS 6. on current medication that impacts acne, such as corticosteroids, JAK inhibitors 7. individuals with dyslipidemia, liver disease 8. bleeding tendency 9. pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| impact of fish oil on efficacy of isotretinoin in acne improvement. baseline, 1 month, 2 months, 3 months the outcome was based on the investigator global assessment (IGA) score and the lesion counts (both inflammatory and non-inflammatory) on the entire face. | — |
Secondary
| Measure | Time frame |
|---|---|
| impact of fish oil on side effects of isotretinoin (mucocutaneous dryness) was measured by 1) skin hydration baseline, 1 month, 2months, 3 months assessing epidermal hydration by using corneometer (measures skin capacitance, which directly varies with hydration) apply on cheek.,impact of fish oil on side effects of isotretinoin (mucocutaneous dryness) was measured by 2) transepidermal water loss baseline, 1 month, 2months, 3 months TEWA meter (g/m2/hr),impact of fish oil on side effects of isotretinoin (mucocutaneous dryness) was measured by 3) sebum level of skin surface baseline, 1 month, 2months, 3 months sebumeter,impact of fish oil on side effects of isotretinoin (mucocutaneous dryness) was measured by 4) skin pH baseline, 1 month, 2months, 3 months pH meter,impact of fish oil on side effects of isotretinoin (hypertriglyceridemia). baseline, 3 months blood for lipid profiles,impact of fish oil on side effects of isotretinoin (elevated liver enzymes). baseline, 3 months blood for AST, ALT,impact of fish oil on side effects of isotretinoin (mucocutaneous dryness) was evaluated using 5) questionnaires. 1 month, 2months, 3 months questionnaires by Patients | — |
Countries
Thailand
Contacts
Public ContactChanat Kumtornrut
Faculty of Medicine Chulalongkorn University
Outcome results
None listed