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Cold snare polypectomy with submucosal injection versus cold snare polypectomy without submucosal injection for colorectal polyps 3-9 mm: a randomized controlled trial

Cold snare polypectomy with submucosal injection vs. cold snare polypectomy without submucosal injection for colorectal polyps 3-9 mm: a randomized controlled trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20240805001
Enrollment
340
Registered
2024-08-05
Start date
2025-05-06
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal polyps colonoscopy, polyp, cold snare polypectomy, submucosal injection

Interventions

Polyp is removed by cold snare polypectomy with SnareMaster plus (Olympus Corporation, Tokyo, Japan). Normal saline solution mixed with indigo carmine is injected into submucosal layer before performi
Experimental Procedure/Surgery,Active Comparator Procedure/Surgery
cold snare polypectomy with submucosal injection,conventional cold snare polypectomy

Sponsors

None listed

Eligibility

Sex/Gender
All
Age
40 Years to 79 Years

Inclusion criteria

Inclusion criteria: Patients aged 40-79 years, and undergoing screening or surveillance colonoscopy with at least one endoscopically diagnosed adenomatous or sessile serrated polyps measuring 3-9 mm.

Exclusion criteria

Exclusion criteria: The participants with endoscopically suspicious of malignant polyps, inflammatory bowel disease, familial polyposis syndrome, use of anticoagulant or antiplatelet therapy, known coagulopathy, pregnancy, or those who do not consent to participate in the study will be excluded.

Design outcomes

Primary

MeasureTime frame
Incomplete resection rate 1 month after the procedure Percent

Secondary

MeasureTime frame
En bloc resection rate At the day of colonoscopy Percent,Procedural time At the day of colonoscopy Second,Specimen fragmentation rate At the day of colonoscopy Percent,Procedural adverse events until 1 month after procedure Percent,Resection depth assessed by the pathologists (included muscularis mucosae or submucosa or not) 1 month after procedure Percent

Countries

Thailand

Contacts

Public ContactSukit Pattarajierapan

King Chulalongkorn Memorial Hospital

sukit.p@chulahospital.org66818123359

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026