The patients with confirmed SARS-CoV-2 infection who presented with mild symptoms. Andrographis paniculata, favipiravir, COVID-19, traditional herbal medicine, symptom relief, pneumonia, viral clearance
Conditions
Interventions
AP capsule contained 400 mg of Andrographis paniculata (Burm.f.) Wall. ex Nees powder. The dosage of 4 capsules per meal, three times a day (with an AP content of 180 mg per day) for a duration of fiv
Andrographis paniculata,Favipiravir,Placebo
Sponsors
Sirirraj research and development fund, Faculty of medicine Siriraj Hospital, Mahidol University, Thailand
No Secondary Sponsor
Eligibility
Sex/Gender
All
Age
18 Years to 59 Years
Inclusion criteria
Inclusion criteria: Enrolled participants who presented with at least one mild COVID-19 symptom (fever, cough, sore throat, muscle aches, loss of taste or smell, nasal congestion, sputum, shortness of breath, headache, or diarrhea). Inclusion required laboratory confirmation of SARS-CoV-2 infection with RT-PCR within 72 hours.
Exclusion criteria
Exclusion criteria: Exclusion criteria included significant chronic obstructive pulmonary disease (COPD), chronic kidney disease (CKD), heart disease, cardiovascular disease, liver cirrhosis, obesity (body weight more than 90 kg), uncontrolled diabetes, immunodeficiency (lymphocyte count less than 1,000 cell/cm3), pregnancy or plans for pregnancy, allergy to Andrographis paniculata (AP) or favipiravir, ongoing use of AP or herbal medicine containing AP within 7 days prior to enrollment, and use of antiplatelet or anticoagulation medications (clopidogrel, warfarin, aspirin). Prior to their involvement in the study, all participants provided written informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pneumonia 10 days chest X-ray ,Changes of vital signs 10 days value,Detection of SARS-CoV-2 10 days RT-PCR,blood oxygen saturation 10 days pulse oximetry,blood chemistry 10 days liver function test, kidney function test, lipid profile, CBC | — |
Secondary
| Measure | Time frame |
|---|---|
| body element changes after treatment 10 days questionnaire,abnormal electrocardiogram 10 days Electrocardiography,sore throat 10 days Self-assessment,adverse events (rashes) 10 days doctor assessment ,aches and pains 10 days Self-assessment ,headache 10 days Self-assessment,phlegm 10 days Self-assessment,shortness of breath 10 days Self-assessment,diarrhea 10 days Self-assessment,loss of smell 10 days Self-assessment,loss of taste 10 days Self-assessment,adverse events (gastrointestinal symptoms) 10 days doctor assessment | — |
Countries
Thailand
Contacts
Public ContactChairat Permpikul
Faculty of Medicine Siriraj Hospital
Outcome results
None listed