Moderate-to-severe acne vulgaris receiving isotretinoin or doxycycline. Isotretinoin
Conditions
Interventions
Moderate-to-severe acne vulgaris patients receiving low-dose isotretinoin (0.1-0.4 mg/kg/day or fixed dose 10 mg/day) within 1 week at Dermatology clinic, King Chulalongkorn Memorial hospital,Moderate
Screening,Screening
Low-dose Isotretinoin,Doxycycline
Sponsors
Chanat Kumtornrut
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Males and females aged 18-50 years, sexually active. 2. Diagnosed with moderate-to-severe acne vulgaris. 3. Receiving low-dose isotretinoin (0.1-0.4 mg/kg/day or a fixed dose of 10 mg/day) or doxycycline 200 mg/day within the past week. 4. Understanding the Thai language. 5. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe medical conditions. 2. History of psychiatric disorders. 3. High risk of depression defined by PHQ-9 scores equal to or greater than 7. 4. Concomitant diseases affecting acne severity and sexual function, e.g., PCOS. 5. Current use of oral contraceptives or anti-androgenic medication. 6. History of isotretinoin use within the past 6 months. 7. Breastfeeding or pregnancy. 8. Postmenopausal women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arizona Sexual Experience Scale (ASEX) 0, 3-4 months Self-questionnaires for evaluating sexual function (for male patients) reported as scores (range 5-30),The International Index of Erectile Function (IIEF-5) 0, 3-4 months Self-questionnaires for evaluating sexual function (for male patients) reported as scores (range 5-25),Female Sexual Function Index (FSFI) 0, 3-4 months Self-questionnaires for evaluating sexual function (for female patients) reported as scores (range 2-36) | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient Health Questionnaire, PHQ-9 0, 3-4 months Self-questionnaire to screen patients with high risk of depression (scores more than 7),Dermatology Life Quality Index, DLQI 0, 3-4 months Self-questionnaire for evaluating quality of life reported as scores (range 0-30),Personal informations (Age, BMI, marital status, partner sex, frequency of sexual intercourse, income, occupation, educational level, underlying diseases, current medications, alcohol use, smoking) Baseline Demographic data reported as mean and standard deviation (for numerical data) or frequency and percentage (for categorical data) | — |
Countries
Thailand
Contacts
Public ContactChanat Kumtornrut
Faculty of Medicine, Chulalongkorn University
Outcome results
None listed