Acute kidney injury Acute kidney injury Continuous kidney replacement therapy Citrate
Conditions
Interventions
4% TSC will be used as hypertonic citrate solution. Initial target citrate dose at 4 mmol/L.,CitraHF or prismocitrate 18/0 will be used as isotonic citrate solution. Initial target citrate dose at 4 m
Active Comparator Drug,Active Comparator Drug
Hypertonic citrate,Isotonic citrate
Sponsors
Excellence Center for Critical Care Nephrology, Faculty of Medicine, Chulalongkorn University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Absolute indications for CRRT 2. Start RCA within 8 hours after CRRT initiation 3. Intention to provide full intensive care treatment for at least 3 days
Exclusion criteria
Exclusion criteria: 1. Persistent and severe lactic acidosis (lactate >=8 mmol/L and pH <7.2 in 2 consecutive measurements for >2 hours) 2. Acute liver failure 3. Kidney transplant within last 12 months 4. Refused consent 5. Do not resuscitate 6. Moribund state (expected death within 24 hours)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total filter life span End of circuit use Hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Adjusted filter life span End of circuit use Hours,ICU mortality ICU discharge Rate,Hospital mortality Hospital discharge Rate,ICU length of stay ICU discharge Days,Hospital length of stay Hospital discharge Days,Citrate adverse effects End of study Rate,Other adverse effect End of study Rate | — |
Countries
Thailand
Contacts
Public ContactNattachai Srisawat
Chulalongkorn University
Outcome results
None listed