Efficacy of probiotics in treatment of Chronic Sinusitis . Chronic Sinusitis, Probiotics .
Conditions
Interventions
Probiotics capsule 500 mg oral daily dose for 8 weeks
, Placebo capsule 500 mg oral daily dose for 8 weeks
Active Comparator Drug,Placebo Comparator Drug
Sponsors
HRH Princess Maha Chakri Sridhorn Medical center
No Study Secondary Sponser
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years 2. Confirm diagnosis of Chronic Sinusitis ,measure from EPOS 2020 who presents with symptoms more than 12 weeks
Exclusion criteria
Exclusion criteria: Exclusion Criteria : * 1.chronic sinusitis without nasal polyp , patient who was diagnosed Chronic sinusitis less than 6 month, patient who present with chronic sinusitis and has indication for surgery . 2.nasal mass or nasal cancer or sinus cancer 3.petient with adverse effect of probiotics 4.pregnancy or lactating woman 4.caution with probiotic e.g.immunocompromise, prosthetic heart valves, impaired intestine function, central venous catheter, jejunostomy, broad-spectrum antimicrobials and poorly control diabetes mellitus 5 7. Patient who allegic to hypromellose , who has history of isomalt allergy or silicon dioxide . 9. Patient who receive anti Antibiotic within 1 week prior
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study the efficacy of probiotics in treatment Chronic sinutis comparison with placebo controlled 1st visit , 8 weeks Lund-Kennedy endoscopy scoring system ,Visual analogue scale , Sinu nasal outcome test 22 | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison the quality of life and side effect of probiotics in treatment Chronic sinusitis 8 weeks Lund-Kennedy endoscopy scoring system ,Visual analogue score ,Sinu nasal outcome test 22 | — |
Countries
Thailand
Contacts
Public ContactPAUNWAT WONGWATTANA
Srinakharinwirot University
Outcome results
None listed