Children aged 9-12 years who are healthy with previous immunization with either pentavalent or hexavalent vaccines. Informed consent obtained from parents/guardians. diphtheria tetanus pertussis hepatitis B measles mumps rubella
Conditions
Interventions
This group received hexavalent vaccines at month 2,4,6, 18.,This group received pentavalent vaccines at month 2,4,6, 18.
Prevention,Prevention
hexavalent,pentavalent
Sponsors
Ratchadapiseksomphot Endowment Fund, Chulalongkorn University
Eligibility
Sex/Gender
All
Age
9 Years to 12 Years
Inclusion criteria
Inclusion criteria: Children aged 9-12 years Previous immunization with either pentavalent or hexavalent vaccines Informed consent obtained from parents/guardians
Exclusion criteria
Exclusion criteria: 1. Serious underlying medical condition e.g. genetic disorder such as Down syndrome, children in immunosuppressive state or receiving immunosuppressive agents, human immunodeficiency virus infection, chronic lung or heart disease, chronic liver or kidney disease, history of chronic or recurrent infections. 2. Primary or secondary humoral immune disorders 3. History of adverse reactions to vaccines 4. Participation in another clinical study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| antibody levels to hepatitis B annually ELISA | — |
Secondary
| Measure | Time frame |
|---|---|
| antibody levels to DTP Annually ELISA,antibody levels to MMR Annually ELISA | — |
Countries
Thailand
Contacts
Public ContactNasamon Wanlapakorn
Chulalongkorn University
Outcome results
None listed