Surgical site infection (SSI) is a frequent complication following resection of soft tissue sarcoma (STS), with an incidence of 8-14%. Using prophylactic antibiotics decreases SSIs. However, there is ongoing debate regarding the optimal duration of prophylactic antibiotics. Antibiotics, Soft tissue sarcoma, Orthopedic oncology, Randomized controlled trial, Statistical analysis plan
Conditions
Interventions
Cefazolin 2 grams intravenous every 8 hours for 24 hours, then NSS intravenous every 8 hours until remove suction drain,Cefazolin 2 grams intravenous every 8 hours until remove suction drain
Experimental Drug,Active Comparator Drug
Postoperative antibiotic prophylaxis 24-hour, Postoperative antibiotic prophylaxis until remove suction drain
Sponsors
Department Orthopaedic Surgery
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age 18 years old or older 2. Provisional diagnosis as soft tissue sarcoma 3. Plan for soft tissue sarcoma resection at musculoskeletal area 4. Plan for drain insertion after surgery
Exclusion criteria
Exclusion criteria: 1. Penicillin allergy 2. Previous culture reported that microbes cannot be treated by cephalosporins 3. Previous antibiotic use within 7 days before surgery 4. Previous infection at surgical site 5. Chronic kidney disease (creatinine clearance less than 10 ml/min), required hemodialysis or kidney transplant 6. History of chemotherapy less than 3 weeks 7. Immunocompromised patient 8. Pathological report shown no soft tissue sarcoma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Surgical site infection rate 2, 4 weeks Percentage of surgical site infection rate | — |
Secondary
| Measure | Time frame |
|---|---|
| Medical complications (i.e. nosocomial infection, pressure ulcer, heart failure) 2, 4 weeks Count the point | — |
Countries
Thailand
Contacts
Public ContactApichat Asavamongkolkul
Siriraj Hospital
Outcome results
None listed