Pateints with Severe symptomatic hyponatremia. Severe symptomatic hyponatremia
Conditions
Interventions
We use 3 % NaCl iv bolus in 30 min until achieve target pNa more than 5 mEq/L and improve Glasglow Coma Scale.,We use 3 % NaCl iv drip start 1 ml/Kg/hr and adjust according to protocol to achieve targ
Experimental Drug,Active Comparator Drug
3 % NaCl bolus ,3 % NaCl drip
Sponsors
Orakan Lanwong
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1.Patients who are visitting at Emergency room or admitted in Kranuan Crown Prince hospital. 2.Age older than 18 years old. 3.Glucose-corrected plasma sodium less than 125 mmol per L. 4.Severe symptoms (vomiting, drowsy, seizure and coma). 5.Body weight more than or equal 45 kg.
Exclusion criteria
Exclusion criteria: 1.Hypotension (systolic blood pressure less than 90 mmol per L) or mean arterial pressure less than 70 mmol per L. 2.Pregnancy or breast feeding. 3.Previous history of volume overload or congestive heart failure (CHF). 4.Patients with lung congestion from chest X-ray. 5.Chronic kidney disease with edema. 6.Cirrhosis with edema. 7.Patients with symptoms of CAD, VHD and arrythmia. 8.Patients with brain injuries or increased intracranial pressure that is not from hyponatremia. 9.Patients who have critical illness suc as respiratory failure,sepsis or multiorgan failure 10.Deny consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to achieve target in pNa and improvement of Glasglow Coma Scale (GCS). at 6 hours after treatment minutes | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in pNa 6 hr after treatment mEq/L ,overcorrection rate in 24th and 48 th hr percent,Osmotic demyelination rate 48 hr percent ,mortality rate 30 days percent | — |
Countries
Thailand
Contacts
Public ContactOrakan Lanwong
Kranuan Crown Prince Hospital
Outcome results
None listed