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Efficacy of Gingival Depigmentation by Conservative Injectable Vitamin c in Comparison with Scalpel Surgery: A Split Mouth Design

Efficacy of Gingival Depigmentation by Conservative Injectable Vitamin c in Comparison with Scalpel Surgery: A Split Mouth Design

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20240715003
Enrollment
20
Registered
2024-07-15
Start date
2023-01-05
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Clinical measurements of melanin pigmentation index and gingival pigmentation index and digital photographs using ImageJ software program at 1st ,2nd ,3rd week post surgical and during Vitamin C injection then finally reevaluation after 6 months. Vitamin C, depigmentation, scalpel surgery, melanosomes, gingival melanin hyperpigmentation

Interventions

Intragingival injection of 1- 1.5 ml (200-300mg concentration) of vitamin C was done by using syringes 30 gauge (insulin syringe). The shaft of the needle was bent 45 with a bevel of the needle orient
Experimental Procedure/Surgery,Experimental Procedure/Surgery
Vitamin C injection,Scalpel surgery

Sponsors

Hospital of stomatology of Sana'a University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
19 Years to 36 Years

Inclusion criteria

Inclusion criteria: All selected patients were healthy and free from any systemic diseases. females. Patient with physiologic gingival melanin hyperpigmentation in esthetic region. Patient age between 18-50 years and patient willing to depigmentation

Exclusion criteria

Exclusion criteria: 1. patient who takes drugs encourages gingival pigmentation. 2. Smokers. 3. Patients having compromised systemic health. 4. Pregnant and lactating patients. 5. Patients are unable to complete the follow-up visits. 6. Patient with thin gingival biotype. 7. Patients with periodontitis.

Design outcomes

Primary

MeasureTime frame
gingival pigmentation measurment at baseline, after one week, two weeks, three weeks and six months later Gingival pigmentation index, melanin pigmentation index and digital photography using ImageJ software

Secondary

MeasureTime frame
Pain, itchy and patient satisfaction Pain and itchy were reported by the patient after the surgical procedure and following each injection visit using visual analogue scale. Patient satisfaction was performed after three to six months Pain and itchy were reported by the patient using visual analogue scale. Patient satisfaction was performed using five graded self-assessment analysisle.

Countries

Yemen

Contacts

Public ContactManal AlHajri

periodontology department, Sanaa university

dent.manal@yahoo.com00967779212007

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026