Quality of recovery Postoperative pain Postoperative nausea and vomiting Intravenous lidocaine infusion Quality of recovery Laparoscopic gynecological surgery
Conditions
Interventions
2% lidocaine 1.5 mg/kg bolus in 10 minutes since induction then continuous drip 1.5 mg/kg/hour until end of surgery,Normal saline infusion in same amount and rate as lidocaine
Experimental Drug,Placebo Comparator No treatment
Intravenous lidocaine infusion,Normal saline
Sponsors
Rajavithi Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients who scheduled for elective laparoscopic gynecological surgery for benign diseases 2. ASA physical status 1-2
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Body weight < 40 kg or BMI > 35 kg/m2 3. History of local anesthetic allergy 4. History of cardiac arrhythmia 5. Cirrhosis or elevated AST or ALT >/= 2x of normal upper limit 6. GFR </= 60 ml/min/1.73m2 7. Neurological disease 8. NSAID or sulfa drugs allergy 9. History of GI bleeding or peptic ulcer 10. Regular use of analgesics 11. Unable to fully understand Thai and access questionnaire and pain rating
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of recovery 24 hours after surgery Thai QoR-35 score | — |
Secondary
| Measure | Time frame |
|---|---|
| Total 24-hour opioid consumption During 24 hours after surgery Record dose in milligram,Postoperative pain PACU, 4,8,12,24 hours after surgery Numeric rating scale,Postoperative nausea and vomiting During 24 hours after surgery Record number of times required anti-emetic drugs,Sedation Arrival time at PACU and 1 hour after surgery Ramsay sedation score,Incidence of severe pain During 24 hours after surgery Number of patients who have severe pain | — |
Countries
Thailand
Contacts
Public ContactPanramon Vanichvithya
Rajavithi Hospital
Outcome results
None listed