Comparison of Salivary Fluoride Levels Following the Application of Rice-Based and Commercial Fluoride Gels: A Randomized Crossover Trial

Comparison of salivary fluoride levels following 1.23% acidulated phosphate fluoride gel between commercial fluoride gel, fluoride non glutinous rice gel and fluoride glutinous rice gel application.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20240707002

Enrollment

Registered

2024-07-07

Start date

2024-04-30

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy human volunteers salivary fluoride levels

Interventions

Participants will receive commercial fluoride gel (standard formulation) according to manufacturer&#039

s instructions.,Participants will receive fluoride non-glutinous rice gel according to manufacturer&#039

s instructions.,Participants will receive commercial fluoride glutinous rice gel according to manufacturer&#039

s instructions.

Active Comparator Drug,Experimental Drug,Experimental Drug

Application of commercial fluoride gel (standard formulation).,Application of fluoride non-glutinous rice gel.,Application of fluoride glutinous rice gel.

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1.Healthy human volunteers age between 20-40 years. 2.They should have at lease 24 sound dentition (no active dental caries or extensive restorations). 3.They must be willing and able to comply with study procedures, including providing informed consent. 4.Normal non-stimulated saliva flowrate (0.3-0.4 ml/min)

Exclusion criteria

Exclusion criteria: 1.Pregnancy and lactation are excluded due to potential hormonal changes affecting saliva composition. 2.Individuals with a history of fluoride hypersensitivity are excluded to avoid adverse reactions.

Design outcomes

Primary

Measure	Time frame
Salivary Fluoride Levels Before fluoride application, immediately after application, after application for 5, 10, 15, 20, 30, 45, 60 minutes Salivary Fluoride Levels using Fluoride ISE (Fluoride Ion Selective Electrode)	—

Secondary

Measure	Time frame
Area under curve of salivary fluoride level by time Before fluoride application, immediately after application, after application for 5, 10, 15, 20, 30, 45, 60 minutes measurement in ppm*minute	—

Countries

Thailand

Contacts

Public ContactNatdanai Yingpukdee

Chiang Mai University

natdanai.yi@outlook.com0876218508

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026