Indocyanine Green Angiography for Real-time Evaluation of Nasoseptal Flap Vascularity and Perfusion

Intraoperative indocyanine green angiography for evaluation of nasoseptal flap vascularization in endoscopic skull base surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20240706007

Enrollment

150

Registered

2024-07-06

Start date

2017-01-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who underwent endoscopic skull base surgery and required a nasoseptal flap for skull base defect reconstruction. nasoseptal flap indocyanine green endoscopic skull base surgery cerebrospinal fluid leak skull base reconstruction flap necrosis

Interventions

After obtaining patient consent, each patient will be enrolled in the study. Following induction of anesthesia, a dose of 12.5 milligrams of indocyanine green (ICG) will be administered intravenously

Experimental Procedure/Surgery

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Patients aged 18 years or older. 2.Patients who underwent endoscopic skull base surgery via the nasal cavity

Exclusion criteria

Exclusion criteria: 1.Patients who have previously undergone endonasal surgery. 2.Patients with allergies to ICG, iodine-containing substances, or seafood. 3.Pregnant or breastfeeding patients. 4.Patients with chronic renal failure (GFR less than 45 ml/min/1.73 m2) or those requiring dialysis.

Design outcomes

Primary

Measure	Time frame
Classification of blood vessel characteristics supplying the nasal septum visualized after ICG injection. after injection number	—

Secondary

Measure	Time frame
Enhancement patterns of the nasal septum vasculature after its placement for skull base defect reconstruction at the time of flap placement number,Relationship between the characteristics of blood vessels supplying the nasal septum after ICG injection and the pattern of flap enhancement post-surgery. at the time of flap placement percent,Relationship between the rate of cerebral vascular leakage and the characteristics of the blood vessels supplying the nasal septum postoperative period percent,Flap necrosis postoperative period number,Relationship between the rate of flap necrosis and the characteristics of the blood vessels supplying the nasal septum postoperative period percent,Relationship between the enhancement pattern of the flap on CT scan and the characteristics of the blood vessels supplying the nasal septum postoperative period percent	—

Measure

Time frame

Enhancement patterns of the nasal septum vasculature after its placement for skull base defect reconstruction at the time of flap placement number,Relationship between the characteristics of blood vessels supplying the nasal septum after ICG injection and the pattern of flap enhancement post-surgery. at the time of flap placement percent,Relationship between the rate of cerebral vascular leakage and the characteristics of the blood vessels supplying the nasal septum postoperative period percent,Flap necrosis postoperative period number,Relationship between the rate of flap necrosis and the characteristics of the blood vessels supplying the nasal septum postoperative period percent,Relationship between the enhancement pattern of the flap on CT scan and the characteristics of the blood vessels supplying the nasal septum postoperative period percent

—

Countries

Thailand

Contacts

Public ContactRaywat Noiphithak

Department of Surgery, Faculty of Medicine, Thammasat University

raywat_n@tu.ac.th6629269523

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026