Colorectal cancer Colorectal cancer Colorectal surgery Nutritional supplementation Probiotics Time to bowel movement Time to flatus Length of stay Complications
Conditions
Interventions
Not having any nutritional supplementation at all ,Nutritional supplementation but lacking the probiotic agent (Nestle Isocal).,Nutritional supplementation with the probiotic agent (Nestle Boost Optim
No Intervention No treatment,Placebo Comparator Dietary Supplement,Active Comparator Dietary Supplement
Arm A,Arm B,Arm C
Sponsors
Nestle Singapore (Pte) Ltd
Eligibility
Sex/Gender
All
Age
21 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients will be eligible to be recruited into the study if they meet all the following inclusion criteria: a. undergoing elective CRC surgery in which an oncologic resection is planned b. age between 21 and 99 years at the time of consent c. willing to consider oral nutritional supplementation d. on our institution's enhanced recovery after surgery (ERAS) pathway e. able to provide informed consent
Exclusion criteria
Exclusion criteria: Exclusion criteria for this study includes: a. patients with known contraindications to probiotic use b. patients undergoing emergency surgery c. taking any other form of probiotics within one month d. taking oral antibiotics within 7 days of commencement of study e. vulnerable patients including pregnant patients, inmates, and those who are cognitively impaired and therefore are not able to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to bowel movement daily, for 30 days Number of days from surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to first flatus daily, for 30 days Number of days from surgery,Length of stay daily, for 30 days Number of days from surgery,Incidence of infective complications daily, for 30 days Incidence of infective complications,Adverse event relating to probiotic use daily, from 7 days before surgery, till 30 days after surgery Incidence of adverse events | — |
Countries
Singapore
Contacts
Public ContactDedrick Kok Hong Chan
National University Hospital
Outcome results
None listed