Healthy condition Pumpkin Cheese, Functional Food, Non-Communicating Diseases (NCDs), Lipid profile
Conditions
Interventions
food set with the placebo cheese per day for 5 days, food set with the pumpkin cheese per day for 5 days
food set with the placebo cheese per day,food set with the functional anthocyanin 2 g per day
Sponsors
Agricultural Research Development Agency (Public Organization)
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Female volunteers aged 18-45 years with normal health. (Use only females because it reduces differences in metabolic rates between males and females.) 2. Body mass index in the normal range (18-25 kg/m2) 3. HOMA-IR less than 2.6 (Cut off insulin resistance) 4. Stress is at a level not exceeding moderate stress. (score less than 12) from the evaluation with the depressive mood questionnaire Anxiety and stress (DASS-21) 5. Can communicate Can read and write Thai.
Exclusion criteria
Exclusion criteria: 1. Have a chronic illness that requires continuous medication, including cardiovascular disease, lung disease, cancer, diabetes, allergies, liver disease. 2. Have received medicines or products that have the effect of lowering blood sugar, lowering fat, having the effect of antibiotics, anti-inflammatory drugs, laxatives or weight loss drugs in the past 30 days before participating in the research project. 3. Consume probiotic products such as Yakult, yogurt, cheese, or fructo-oligosaccharide. Regularly or more than 3 times per week in the last 30 days before participating in the study. 4. Drink more than 5 alcoholic beverages per day. 5. Smoke cigarettes (at least in the last 30 days) or smoke more than 10 cigarettes per day. 6. Pregnant or plan to become pregnant during the research period. 7. Breastfeeding. 8. Currently participating in other projects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HDL-Cholesterol Baseline, day 1 (at 1, 3, 6 h), and 5 days Laboratory of hospital | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory markers (IL-6, IL-10, IL-17, TNF-alpha), and Serum amyloid-A (SAA) Baseline and 5 days HHPHP laboratory; ELISA method,Lipid profiles (Total Cholesterol, Triglyceride, and LDL-Cholesterol) Baseline, day 1 (at 1, 3, 6 h), and 5 days Laboratory of hospital,Acute-phase proteins (C-reactive protein (CRP) Baseline, day 1 (at 1, 3, 6 h), and 5 days Laboratory of hospital,Fasting blood glucose, Insulin, HOMA-IR, Glucose concentration (AUC) Baseline, day 1 (at 1, 3, 6 h), and 5 days HHPHP laboratory, except Insulin by hospital laboratory, Deoxyguanosine (8OHDG) Baseline and 5 days HHPHP laboratory; ELISA method,Vascular cell adhesion molecule 1 (VCAM1) Baseline and 5 days HHPHP laboratory; ELISA method,Lactobacillus spp. and Bifidobacterium spp.) and Short chain fatty acid Baseline and 5 days HHPHP laboratory; Basic bacterial culture,DASS-21 Baseline and 5 days HHPHP laboratory; Questionair,Physical fitness Baseline and 5 days HHPHP laboratory,Blood flow and Cerebral blood flow Baseline and 5 days HHPHP laboratory | — |
Countries
Thailand
Contacts
Public ContactPraew Kotruchin
Faculty of Medicine, Khon Kaen University
Outcome results
None listed