Prospective randomized clinical trial of accelerated re-epithelialization of split-thickness skin graft donor sites using injectable platelet-rich fibrin (I-PRF)

Prospective randomized clinical trial of accelerated re-epithelialization of split-thickness skin graft donor sites using injectable platelet-rich fibrin (I-PRF).

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20240704001

Enrollment

Registered

2024-07-04

Start date

2023-11-17

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epithelialization of split-thickness skin grafting donor site using direct observation method by senior surgeon. The period of complete or excellent healing will be recorded. Platelet-rich fibrin Injectable platelet-rich fibrin Epithelialization Donor site

Interventions

Tulle gauze is a type of medical dressing used for the treatment of various wound. It helps prevent the dressing from sticking to the wound, making it easier to change without causing further damage t

Experimental Device,Experimental Device

Tulle gauze,Tulle gauze plus injectable platelet-rich fibrin

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients who plan to perform split-thickness skin graft procedure

Exclusion criteria

Exclusion criteria: 1. Hematologic disorder 2. Platelet count less than 100,000 per microliter of blood 3. Severe cardiopulmonary disease or septicemia 4. Severe malnutrition 5. Systemic corticosteroid used within 2 weeks before surgery 6. HIV/ AIDS 7. Pregnancy 8. Inflammation or infection of donor site 9. Loss follow-up patients 10. Patients who refuse to participate in the research project

Design outcomes

Primary

Measure	Time frame
Healing time Open and clean donor site wound at 7 days, 10 days then every day until complete epithelialization Direct observation by senior surgeon	—

Secondary

Measure	Time frame
Epithelial thickness At the day of complete epithelialization Histopathology measurement by pathologist	—

Countries

Thailand

Contacts

Public ContactPremsak Sakarinpanichakul

Buriram Hospital

pkcfriend@yahoo.com0868738737

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026