Efficacy of Transconjunctival Dexamethasone in treatment of upper lid retraction in thyroid eye disease transconjunctival dexamethasone lid retraction thyroid eye disease
Conditions
Interventions
Transconjunctival Dexamethasone in treatment of upper lid retraction in thyroid eye disease
Treatment
Dexamethasone
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Over 18 years old. 2. Patients with thyroid retinopathy have a upper lid retraction less than 1 year, the distance from the center of cornea to the upper eyelid (margin reflex distance1) more than 5 millimeters. 3. Thyroid hormone levels Free T3 and/or Free T4 were within normal at least 3 months before participating in this study. 4. Not smoke or if smoked must abstain more than 6 months before participating in this study.
Exclusion criteria
Exclusion criteria: 1. Have eyelid surgery in the past 6 months before or plan to surgery during participate in this study. 2. Have eye orbital surgery in the past 6 months before or plan to surgery during participate in this study. 3. Have receive treatment with triamcinolone or dexamethasone injection in eyelid before. 4. Have received treatment with other eyelid injections in the past 6 months before. 5. Intra ocular pressure more than 21 mmHg or visual field abnormality or any glaucoma suspect. 6. Smoked in during this study. 7. Have eyelid infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| margin reflex distance 1 (MRD1) at first visit, 1 month, 2 month, 3 month, 6 month, 9 month decrease margin reflex distance more than 1 millimeter or normal upper eyelid position | — |
Secondary
| Measure | Time frame |
|---|---|
| eyelid edema, eyelid injection, chemosis, conjunctival injection at first visit, 1 month, 2 month, 3 month, 6 month, 9 month Slit lamp microscope examination,Clinical activity score (CAS), Graves ophthalmopathy quality of life (GO-QOL) Thai version at first visit, 1 month, 2 month, 3 month, 6 month, 9 month Questionaire test | — |
Countries
Thailand
Contacts
Public ContactPimkwan Jaruampornpan
Faculty of Medicine Siriraj Hospital
Outcome results
None listed