Hypertrophic and keloid scars Hypertrophic scars, keloid scars, polynucleotide, steroid injection
Conditions
Interventions
Participants will be randomly assigned using the Block Randomization method to receive either polynucleotide injection Rejuran,or Triamcinolone acetonide 10mg/ml on Side B of the surgical scar area.
Experimental Drug,Active Comparator Drug
Polynucleotide,Triamcinolone acetonide
Sponsors
none
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: To be eligible for the study, participants must be 18 years or older and generally healthy without severe chronic illnesses. They should have hypertrophic or keloid scars on their abdomen in a linear fashion and be able to attend scheduled medical appointments and adhere to study procedures. Additionally, they must be willing to participate by providing informed consent.
Exclusion criteria
Exclusion criteria: However, individuals are excluded from the study if they have received scar treatments involving injections or laser therapy within the past three months, used silicone sheeting on the scar area at the time of enrollment, or have a history or suspicion of skin infection in the treatment area. Other exclusion criteria include being immunocompromised, having a history of skin cancer, herpes simplex virus infection affecting the skin, abnormal tissue growth disorders, or being pregnant or breastfeeding. Lastly, those who refuse or withdraw consent to participate are also excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy and safety of polynucleotide injection for the treatment of hypertrophic scars and keloids on abdomen 5months Scar volume, redness, darkness, and height will be measured using Antera 3D | — |
Secondary
| Measure | Time frame |
|---|---|
| side effect 5 months redness, swelling, skin peeling, dark spots, and white spots will be assessed by both dermatologists and participants after treatment and at each follow-up visit. | — |
Countries
Thailand
Contacts
Public ContactPimsiri Anansiripun
Ramathibodi hospital
Outcome results
None listed