The cross-sectional study of physical, biochemical and clinical parameters, genetics, and epigenetics of frailty in Thai community-dwelling older people

The comprehensive study of physical frailty in community-dwelling older people

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20240626002

Enrollment

870

Registered

2024-06-26

Start date

2021-12-21

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Frailty status transition in the frail and pre-frail older people Frail, prefrail, pre-frail, robust, frailty status, older, elder, nutrition, kihon, kihon checklist, frail scale, MNA, GPAQ, calf circumference, TGDS-15, depression, cognitive impairment, genetics, epigenetics, DNA methylation, B vitamins

Interventions

A participant was considered robust if they met zero out of the five parameters of the Fried criteria,A participant was considered pre-frail if they met 1-2 out of the five parameters of the Fried cri

Basic Science,Basic Science,Basic Science

Robust,Pre-frail,Frail

Eligibility

Sex/Gender

All

Age

60 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Thai elderly patients age 60 years or older.

Exclusion criteria

Exclusion criteria: 1.Patients who cannot communicate 2.Cognitive impairment ( TMSE <18) 3.Life expectancy <6 months 4.Unstable condition ( Congestive heart failure, Cardiovascular or respiratory failure , Blood pressure <90/60mmHg, or >180/100mmHg, heart rate >100bpm, oxygen saturation < 92%, Respiratory rate 22/min) 5.disabled people 6. people with prosthesis which disturbs body composition measurement by bioelectrical impedance analysis 7.History of hospitalization within 3 months

Design outcomes

Primary

Measure	Time frame
Physical characteristics Cross-sectional at the recruiment chair stand, functional reach, gait speed in 4 meters, hand grip strength, and sit and reach,Blood parameters Cross-sectional at the recruiment chemiluminescence, electrical resistance, hydrodynamic focusing, SLS-haemoglobin, and high-performance liquid chromatography methods and Chronic Kidney Disease Epidemiology Collaboration equation	—

Secondary

Measure	Time frame
Genetics and epigenetics profiles Cross-sectional at the recruiment sanger sequencing, and colorimetric method and Infinium MethylationEPIC array	—

Countries

Thailand

Contacts

Public ContactChanachai Sae Lee

Faculty of Medicine Siriraj Hospital, Mahidol University

chanachai.sae@mahidol.edu024192806

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026