Madu kelulut add-on therapy in Major Depressive Disorders. A Randomized Clinical Trial

The effect of Stingless Bee Honey on BDNF, oxidative stress, depressive symptoms and verbal learning and memory in Major Depressive Disorders. A randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20240621001

Enrollment

Registered

2024-06-21

Start date

2024-12-15

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major depressive disorder Major Depressive Disorder Brain Derived Neurotrophic Factor Oxidative Stress Memory And Learning Test

Interventions

20 grams of the Heterotrigona Itama species of stingless bee honey in liquid form will be administrated to the patients through oral administration. At the same time, intervention group will undergo t

Experimental Dietary Supplement,No Intervention No treatment

Stingless bee honey,Control

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Adults with ages 18 to 65 with Major Depressive Disorder Scores of Beck Depression Inventory Malay version equal or more than 11

Exclusion criteria

Exclusion criteria: Women in pregnancy or breast-feeding. Patients who with honey allergy or stingless bee honey allergy. Currently taking honey not limited to stingless bee honey or taken honey not limited to stingless bee honey in the past one month. Patients with Major Depressive Disorder comorbidity either with generalized anxiety disorder, panic disorder, social anxiety disorder, bipolar disorder, substance-use disorder, suicidal ideation or attempt, dementia, Alzheimer disease, diabetic, hypertension, chronic kidney disease

Design outcomes

Primary

Measure	Time frame
Depressive symptoms Before intervention, at week 4 during the intervention, at week 8 of the intervention Beck Depression Inventory Malay-version	—

Secondary

Measure	Time frame
Oxidative stress Before intervention, at week 4 during the intervention, at week 8 of the intervention Serum malondialdehyde concentrations in blood,Brain derived neurotrophic factors, BDNF Before intervention, at week 4 during the intervention, at week 8 of the intervention Serum BDNF concentrations of blood,Verbal learning and memory Before intervention, at week 4 during the intervention, at week 8 of the intervention Malay version of auditory verbal learning test,Inflammation Before intervention, Before intervention, at week 4 during the intervention, at week 8 of the intervention Serum IL-6 concentrations of blood	—

Measure

Time frame

Oxidative stress Before intervention, at week 4 during the intervention, at week 8 of the intervention Serum malondialdehyde concentrations in blood,Brain derived neurotrophic factors, BDNF Before intervention, at week 4 during the intervention, at week 8 of the intervention Serum BDNF concentrations of blood,Verbal learning and memory Before intervention, at week 4 during the intervention, at week 8 of the intervention Malay version of auditory verbal learning test,Inflammation Before intervention, Before intervention, at week 4 during the intervention, at week 8 of the intervention Serum IL-6 concentrations of blood

—

Countries

Malaysia

Contacts

Public ContactOng Wailoon

Universiti Sains Malaysia

wailoon@student.usm.my097676165

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026