Endometrial biopsy can cause moderate to severe pain during endometrial biopsy. Endometrial biopsy, lidocaine gel, ibuprofen, pain control
Conditions
Interventions
Ibuprofen 400 mg orally 30 minutes before procedure.
with 2% lidocaine gel ,3 mL, apply on all cervical surface and cervical canal.,Ibuprofen 400 mg orally 30 minutes before procedure.
with Placebo ge
Experimental Drug,Placebo Comparator Drug
2% lidocaine gel with ibuprofen,KY jelly with ibuprofen
Sponsors
Khon Kaen Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >=18 years old. 2. Women who had an indication for an endometrial sampling: abnormal uterine bleeding in age >=35 years, age < 35 years with risk factors (history of unoppsed estrogen exposure, failed medical management, persistent abnormal uterine bleeding), abnormal uterine bleeding with tamoxifen taking, postmenopausal bleeding.
Exclusion criteria
Exclusion criteria: 1.Previous history of lidocaine allergy. 2.Previous history of NSAIDs allergy. 3.Previous history of sulfa drugs allergy. 4.History of gastric ulcer, gastritis, gastrointestinal bleeding. 5.Asthma. 6.Uncontrolled hypertension. 7.Bleeding disorder. 8.Kidney disease. 9.Liver disease. 10.G6PD deficiency. 11.Cardiac arrhythmias. 12.Coronary heart disease. 13.Uterine anomaly. 14.Massive vaginal bleeding. 15.Recieves misoprostol for cervical dilation. 16.Inability to give consent or participant in postoperative assessment owing to dementia, cognitive impairment or language barrier. 17. Unable to use visual analogue scale (VAS). 18. Ongoing vagina or cervix or pelvic infection. 19.Combination with endocervical biopsy. 20.Cervical stenosis. 21.Cannot pass instrument into endometriod cavity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score during aspiration during intervention VAS score | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score speculum insertion Before intervention VAS score,Pain score while grasping tenaculum while grasping tenaculum VAS score,Pain score immediately after biopsy immediately after biopsy VAS score,Pain score 10 minutes after procedure 10 minutes after procedure VAS score,Satisfaction score of patients after procedure questionnare,Satisfaction of physicians after procedure questionnare,Additional analgesic requirement after procedure questionnare ,Side effect of lidocaine gel, after procedure questionnare | — |
Countries
Thailand
Contacts
Public ContactKemmanut Tueman
Khon Kaen hospital
Outcome results
None listed