A comparative study of targeted end-tidal carbon dioxide (EtCO2) versus standard EtCO2 management to guide resuscitation in emergency department cardiac arrest: a randomized controlled trial

Status

Recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20240619001

Enrollment

300

Registered

2024-06-19

Start date

2024-04-26

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients experiencing cardiac arrest in the emergency department (EDCA). This includes patients who experienced their first cardiac arrest outside the hospital (OHCA) and then had a recurrent arrest in the emergency department, as well as patients who experienced their first cardiac arrest while already in the emergency department (IHCA). end-tidal carbon dioxide, targeted EtCO2, emergency department cardiac arrest, ROSC, high-quality CPR, improving mortality, reducing mortality

Interventions

ETCO2 at least 10 mmHg,ETCO2 at least 20 mmHg,ETCO2 at least 25% of PCO2 but not less than 10 mmHg

Active Comparator Device,Experimental Device,Experimental Device

ETCO2 at least 10 mmHg,ETCO2 at least 20 mmHg,ETCO2 at least 25%

Eligibility

Sex/Gender

All

Age

15 Years to No maximum

Inclusion criteria

Inclusion criteria: All patients who experience cardiac arrest in the emergency department (EDCA).

Exclusion criteria

Exclusion criteria: 1. Patients younger than 15 years. 2. Cardiac arrest caused by traumatic events. 3. Patients with a do not attempt resuscitate (DNAR) order. 4. Patients showing signs of irreversible death (Livor mortis, Rigor mortis, decapitation, transection, decomposition).

Design outcomes

Primary

Measure	Time frame
Sustained Return of spontaneous circulation Immediately after CPR Sustained ROSC is defined with any of the following for over 20 minutes: palpable carotid pulse, measurable blood pressure, or spontaneous movement by the patient. All without chest compression.,Survival to hospital discharge 30 days after CPR Case record form	—

Secondary

Measure	Time frame
Survival with favorable neurological outcome 30 days after CPR Favorable neurological outcome is defined as a patient's recovery with minimal or no neurological deficits, quantified using Cerebral Performance Category Scale: CPC 1 or CPC 2	—

Countries

Thailand

Contacts

Public ContactWinchana Srivilaithon

Faculty of Medicine, Thammasat University

winchanas@gmail.com66863669260

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026