Patients with dyslipidemia black pepper, blood lipid levels, dyslipidemia
Conditions
Interventions
The volunteer experimental group receives black pepper capsules at a dosage of 500 milligrams per day. Each participant takes one capsule, twice a day, after breakfast and dinner, continuously for a p
Experimental Dietary Supplement,Placebo Comparator No treatment
Black pepper ,Placebo
Sponsors
MFU research funding
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Volunteers will be eligible to participate in the research if they meet the following criteria: 1. Volunteers of both genders 1.1) Aged between 20-34 years with abnormal blood lipid levels, specifically LDL-C levels between 130-189 mg/dL, HDL-C levels less than 40 mg/dL in females or less than 50 mg/dL in males, and triglycerides levels < 400 mg/dL, or 1.2) Aged between 35-60 years with abnormal blood lipid levels, specifically LDL-C levels between 100-130 mg/dL, HDL-C levels less than 40 mg/dL in females or less than 50 mg/dL in males, and triglycerides levels < 400 mg/dL 2. Body mass index (BMI) between 18-35 kg/m2 3. Diagnosed as a first-time high blood cholesterol patient by the current physician 4. At risk of heart and vascular diseases with a 10-year risk assessment using the Thai CV Risk Score of less than 10% 5. Effective communication skills 6. Willing and able to comply with the study requirements
Exclusion criteria
Exclusion criteria: Volunteers will not be eligible to participate in the research if they have: 1. Abnormal blood lipid levels due to hypothyroidism, nephrotic syndrome, or impaired kidney function (serum creatinine > 1.5 milligrams per deciliter), or have Type 1 or uncontrolled Type 2 diabetes. 2. Consumed other herbal remedies, medications, or dietary supplements affecting blood lipid levels such as steroids, tegretol, cyclosporine, fish oil, fibrates, cholesterol absorption inhibitors, niacin, bile acid sequestrants, statins, probucol, thiazides, progestogens, estrogens, testosterone, beta-blockers, glucocorticoids, etc., that cannot be discontinued. 3. Systolic blood pressure greater than or equal to 130 millimeters of mercury (mm Hg) or diastolic blood pressure greater than or equal to 80 mm Hg. 4. Not taken antihypertensive medications or heart disease medications. 5. Participated in other research projects (except for non-interfering studies such as surveys). 6. A history of allergy to black pepper or other herbal remedies. 7. High-risk factors for heart and vascular diseases, including existing coronary artery disease and other conditions equivalent to heart disease, such as ischemic stroke, transient ischemic attack, peripheral artery disease, aortic aneurysm, etc. 8. Liver cancer or liver function greater than the standard criteria, or impaired kidney function defined as a glomerular filtration rate (GFR) less than 60 milliliters per minute per 1.73 square meters (ml/min/1.73 m2). 9. Taken weight-reducing medications in the past 6 months. 10. Engaged in regular strenuous physical activity. 11. Strictly controlled their diet. 12. Pregnant, planning to become pregnant, breastfeeding, or unwilling to use medically acceptable birth control methods while participating in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| lipid profile at week o (baseline) and week 12 (the end of study) lab investigation | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver and renal function tests at week 0 (baseline) and week 8 lab investigation,Adverse events at week o (baseline), week 8, and week 12 (the end of study) Interview | — |
Countries
Thailand
Contacts
Public ContactNanthakarn Woottisin
School of Integrative Medicine, Mae Fah Luang University, Muang, Chiang Rai 57100, Thailand
Outcome results
None listed