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THE ROLE OF mRNA EXPRESSION OF THYMIDILATE SYNTHASE (TS), METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR), AND DIHIDROPYRIMIDIN DEHYDROGENASE (DPD) AS PREDICTORS OF NEOADJUVANT CHEMOTHERAPY RESPONSE OF 5FU REGIMEN IN ADVANCED COLORECTAL CANCER

THE ROLE OF mRNA EXPRESSION OF THYMIDILATE SYNTHASE (TS), METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR), AND DIHIDROPYRIMIDIN DEHYDROGENASE (DPD) AS PREDICTORS OF NEOADJUVANT CHEMOTHERAPY RESPONSE OF 5FU REGIMEN IN ADVANCED COLORECTAL CANCER

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
TCTR
Registry ID
TCTR20240618004
Enrollment
50
Registered
2024-06-18
Start date
2024-02-21
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with the colorectal cancer (adenocarcinoma) and was given neoadjuvant chemotherapy with (Capecitabine-Oxaliplatin regimen. Colorectal Cancer Chemotherapy predictor

Interventions

Response Chemotherapy,No response Chemotherapy
Treatment,Treatment
Group 1,Group 2

Sponsors

Self funding
Lead Sponsor

Eligibility

Sex/Gender
All
Age
17 Years to No maximum

Inclusion criteria

Inclusion criteria: The participants in this study were stage III and IV colorectal cancer, with histopathological results of adenocarcinoma obtained by biopsy and were willing to receive adjuvant chemotherapy with Capecitabine + Oxaliplatin.

Exclusion criteria

Exclusion criteria: We excluded damaged tissue sample, drop-out patients from chemotherapy follow-up, and pathology results of signet ring cell carcinoma and mucinous carcinoma.

Design outcomes

Primary

MeasureTime frame
mRNA Expression DIHIDROPYRIMIDIN DEHYDROGENASE (DPD), THYMIDILATE SYNTHASE (TS), and METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) gene Before and after Chemotherapy Capecitabine + Oxaliplatin. Fold change mRNA expression—

Secondary

MeasureTime frame
Characteristic data, Tumor size, and carcinoembryonic antigen (CEA) levels When patien admitted to our hospital, Before and after Chemotherapy Capecitabine + Oxaliplatin. age, sex, and colorectal cancer grading, tumor size, and response chemotherapy—

Countries

Indonesia

Contacts

Public ContactElvida Christi Tahiya

Hasanuddin University

viviebedah2011@gmail.com062411585984

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026