Effectiveness of botulinum toxin injection into masseter muscle to lower face appearance and masticatory function

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20240617001

Enrollment

Registered

2024-06-17

Start date

2024-07-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy human volunteers and no history of the botulinum toxin injection into masseter muscle within 1 year Botulinum toxin, Masseter, 3D Face scan, Questionnaires

Interventions

The Botulinum toxin brand&#039

s name is Nabota from Daewoong Pharmaceutical (Seoul, South Korea). Injection dose is 25 units per side with 3-technique injection. All procedures operate under the sterilization and aseptic technique

Experimental Drug

Botulinum toxin injection into masseter muscle

Eligibility

Sex/Gender

All

Age

20 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Healthy volunteer 2. Any sexual, age more than 20 years old 3. Able to read, write and understand Thai language 4. No history of administering botulinum toxin type A into masseter muscle within the last 1 year

Exclusion criteria

Exclusion criteria: 1. History of botulinum toxin allergy 2. Infection at the injected area 3. Patients with neuromuscular disorders (e.g., Myasthenia gravis) 4. Pregnancy

Design outcomes

Primary

Measure	Time frame
Lower face volume (cm3) 0, 4, 8, 12 weeks Soft tissue volume measurement by program	—

Secondary

Measure	Time frame
Patient satisfaction with lower face and jawline 0, 4, 8, 12 weeks Face-Q questionnaires score	—

Countries

Thailand

Contacts

Public ContactNapasorn Sawadsopanont

Mahidol university

napasorn1996@gmail.com66851001447

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026