Osteoarthritis of knee Osteoarthritis of knee S-flurbiprofen plaster Acupuncture points Pain KOOS The Knee Injury and Osteoarthritis Outcome Score
Conditions
Interventions
Volunteers will receive S-flurbiprofen plaster( 40 milligrams per sheet), sized 10x14 square centimaters
They will be instructed on the following usage:
1. Apply one sheet to the painful knee area onc
Active Comparator Drug,Experimental Drug
S-flurbiprofen plaster 40 mg,S-flurbiprofen plaster 20 mg
Sponsors
The faculty of medicine Siriraj hospital
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age 50 years or older. 2. Diagnosed with knee osteoarthritis according to the clinical classification criteria of the American College of Rheumatology, which requires the presence of knee pain and at least 3 out of the following 6 factors: 2.1. Age over 50 years. 2.2. Morning stiffness lasting less than 30 minutes. 2.3. Crepitus (a grating sound or sensation) with knee movement. 2.4. Bony tenderness around the joint. 2.5. Bony enlargement of the joint. 2.6. No palpable warmth in the joint. 3. A numerical rating scale (NRS) for pain while walking between 4 and 7 out of 10, indicating moderate pain. 4. Volunteers must be able to understand Thai through spoken, read, and written communication.
Exclusion criteria
Exclusion criteria: 1.History of allergy to LOCOA flurbiprofen, paracetamol, or NSAIDs. 2. History of peptic ulcer disease, severe blood disorders, kidney disease, liver disease, severe heart disease, severe hypertension (blood pressure more than 180/110 mmHg), asthma, or aspirin-induced asthma. 3. Currently using norfloxacin or prulifloxacin. 4. Presence of skin wounds on the knee. 5. History of receiving physical therapy at a hospital or knee pain relief through acupuncture within 2 weeks before volunteer screening. 6. History of lower limb surgery within 6 months prior to volunteer screening. 7. History of rheumatic diseases affecting the knee, such as rheumatoid arthritis or gout. 8. Spinal or lower limb joint diseases affecting walking ability. 9. Individuals taking medications that affect cartilage or joints.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain severity The results will be measured at three time points: 1. 1 week after starting the medication. 2. 2 weeks after starting the medication. 3. 4 weeks after starting the medication. Numerical rating scale | — |
Secondary
| Measure | Time frame |
|---|---|
| The effectiveness in terms of physical function The results will be assessed at two time points: 1. 2 weeks after starting the medication. 2. 4 weeks after starting the medication. Knee Injury and Osteoarthritic Outcome Score (KOOS),The effectiveness in terms of physical function The results will be assessed at two time points: 1. 2 weeks after starting the medication. 2. 4 weeks after starting the medication. timed up and go test (TUGT) | — |
Countries
Thailand
Contacts
Public ContactKamontip Harnphadungkit
Faculty of medicine, Mahidol university
Outcome results
None listed