patients with dermatitis Oxyresveratrol, Dermatitis, Eczema
Conditions
Interventions
The cream formulation combines 0.1% Oxyresveratrol,Cetyl alcohol, PEG-40 Stearate, 1,3Butylene Glycol, Biosaccharide Gum, Phenoxyethanol, Water,The cream formulation combines 0.5% Oxyresveratrol,Cet
Active Comparator Other,Active Comparator Other,Active Comparator Other,Placebo Comparator Other
oxyresveratrol cream A,oxyresveratrol cream B,oxyresveratrol cream C,oxyresveratrol cream D
Sponsors
Ratchadapisek Research Fund - Type 2
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis with acute to subacute eczema by dermatologist at OPD King Chulalongkorn Memorial hospital 2. At least 1 lesion of acute to subacute eczema with mild severity with 0-12 Eczema Area and Severity Index score
Exclusion criteria
Exclusion criteria: 1. wide-spread systemic skin diseases 2. other skin lesion at the area of study 3. history of ORV allergy 4. pregnant or lactation 5. received topical immunosuppressant or corticosteroid within 2 weeks 6. received oral immunosuppressant or corticosteroid within 4 weeks 7. received live vaccine or immunotherapy within 4 weeks 8. patients with cancer or autoimmune disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eczema Area and Severity Index (EASI) baseline, 3 days, 7 days, 14 days, and 28 days (range from 0 to 72) | — |
Secondary
| Measure | Time frame |
|---|---|
| Biophysical changes of skin (skin hydration, trans-epidermal water loss, pH) baseline, 3 days, 7 days, 14 days, and 28 days using Corneometer (unit from 0 (no water at all) - 120 (on water)), Tewameter (g/m2/h), and pH meter(a scale of 0 to 14) | — |
Countries
Thailand
Contacts
Public ContactJongkonnee Wongpiyabovorn
Faculty of Medicine, Chulalongkorn University
Outcome results
None listed