Oral lichen planus OLP
Conditions
Interventions
Medicines will be administered as mouthwash without dilution at a dosage of 15 mL measured by measuring cups two times daily after breakfast and after dinner. Patients will be instructed to rinse for
Active Comparator Drug,Experimental Drug
0.05% Dexamethasone mouthwash,0.05% Fluocinolone mouthwash
Sponsors
Facultry of dentistry, Chulalongkorn university
The Royal College of Dental Surgeons of Thailand
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 18 years old or above. 2. Patients can provide consent. 3. Patients can communicate well. 4. Patients have been clinically and histopathological diagnosed as OLP or compatible with OLP. 5. Patients have bilateral lesions with modified Thongprasom sign score at least 3 on both sides at the first visit of the study 6. Patients' NRS scores are at least 3 on the first visit of the study. 7. Patients present symptoms, corresponding to erosive/ulcerative or atrophic type of OLP. 8. OLP patients have no history of corticosteroid usage for at least 3 months.
Exclusion criteria
Exclusion criteria: 1. Patients have histopathologic evidence of dysplasia. 2. Patients refuse to follow drug prescriptions. 3. Patients on long-term systemic corticosteroid therapy for other reasons that could not be discontinued. 4. Patients have uncontrolled diabetes mellitus or HbA1c > 8% or Fasting plasma glucose (FPG) > 180 mg/dl. 5. Patients have severe dry mouth with additive score of the Challacombe Scale of Clinical Oral Dryness > 7. 6. Patients have current immunosuppressant usage. 7. Patients have any active bacterial/fungal/viral infections at examination visit. 8. Patients have OLCL. 9. Patients have OLL-GVHD or history of allogenic bone marrow transplantation. 10. Patients have evidence of heavy smoking within the past 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total modified Thongprasom sign score at 1 months after end of the intervention Clinical examination by researcher | — |
Secondary
| Measure | Time frame |
|---|---|
| Numeric rating scale at 1 months after end of the intervention Patient reported outcome using a questionnaire interview,Oral Impact on Daily Performance(OIDP) score at 1 months after end of the intervention Patient reported outcome using a questionnaire interview,Fungal colony count at 1 months after end of the intervention Fungal colony count on Sabouraud's dextrose agar | — |
Countries
Thailand
Contacts
Public ContactPanipak Assawasongsilp
Chulalongkorn university
Outcome results
None listed