Hyperglycemia Increase of blood glucose Postoperative nausea and vomiting Dexamethasone Postoperative nausea and vomiting Blood glucose Hyperglycemia Spinal anesthesia
Conditions
Interventions
Dexamethasone 10 mg diluted in normal saline up to 10 ml intravenous single dose,Dexamethasone 5 mg diluted in normal saline up to 10 ml intravenous single dose ,Normal saline 10 ml intravenous single
Dexamethasone 10 mg,Dexamethasone 5 mg,Normal saline
Sponsors
Rajavithi Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients who scheduled for elective surgery under spinal anesthesia, 2. Have no diabetes mellitus, 3. Baseline blood sugar < 125 mg/dl, 4. ASA physical status I-II, 5. Apfel score 2 or more
Exclusion criteria
Exclusion criteria: 1. BMI<18.5 or > 40 kg/m2, 2. Steroid use within 30 days, 3. Allergy to study drugs, 4. Epilepsy, GI bleeding, gut obstruction, 5. Taking medications with extrapyramidal side effects, 6. Cirrhosis child B and C, 7. CKD stage 3-5 (GFR<60 ml/min), 8. Peptic ulcer, 9. Operation more than 4 hours, 10. Convert to general anesthesia, 11. Receive dextrose containing fluid is given during the study period, 12. Pregnancy, 13. Other contraindications of the study drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood glucose 0, 2, 4, 6 and 8 hours after the study drug Dextrostrip | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of hyperglycemia 0, 2, 4, 6 and 8 hours after the study drug Dextrostrip,Postoperative nausea and vomiting 0, 2, 4, 6 and 8 hours after the study drug PONV score | — |
Countries
Thailand
Contacts
Public ContactNattha Prasitthipayong
Rajavithi Hospital
Outcome results
None listed