Patients receiving intravenous colistin Colistin Cystatin C Acute kidney injury
Conditions
Interventions
The dosing algorithm will be only applied from 7:00 AM to 16:30 PM. When an eligible participant is identified, a cystatin C level will be obtained. The clinical pharmacist will then use the cystatin
Active Comparator Drug,Active Comparator Drug
Colistin dosing by eGFRcr-cys (CKD-EPI formula),Colistin dosing by CrCl (Cockcroft-Gault)
Sponsors
Excellence Center for Critical Care Nephrology, Faculty of Medicine, Chulalongkorn University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Enrolled within 24 hours after the first dose of colistin and expected colistin duration >=48 hours) 2. At risk of low muscle mass defined by sarcopenia index <80%
Exclusion criteria
Exclusion criteria: 1. AKI any stage by KDIGO criteria 2012 2. End stage kidney disease 3. History of kidney transplant 4. Pregnancy 5. Received any routes of colistin within 14 days prior to the day of enrollment 6. Expected death within 48 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute kidney injury occurrence Day 14 Event | — |
Secondary
| Measure | Time frame |
|---|---|
| Target colistin trough level (Ctrough) achievement Day 3 Colistin level,AKI maximal severity Day 14 KDIGO 2012 staging,Subclinical AKI Day 14 Urinary TIMP2*IGFBP7, Urinary NGAL,In-hospital death At discharge Event,Treatment failure At discharge Event,Recurrence of infection At discharge Event,Duration of colistin therapy At discharge Day,Hospital length of stay At discharge Day | — |
Countries
Thailand
Contacts
Public ContactNattachai Srisawat
Chulalongkorn University
Outcome results
None listed