Post menopausal women who have genitourinary symptoms of menopause Vaginal laser therapy, Vaginal symptoms, Vaginal lactobacillus
Conditions
Interventions
Postmenopausal women diagnosed with vulvovaginal atrophy who undergo treatment with fractional micro-ablative CO2 laser therapy.
Treatment
Postmenopausal women diagnosed with vulvovaginal atrophy
Sponsors
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Eligibility
Sex/Gender
Female
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age 50 - 70 years 2. Menopausal status: Absence of menstruation for at least 12 months 3. Being diagnosed with VVA based on medical records. [Having at least one symptom of vaginal atrophy on medical record (Vaginal Dryness, Vaginal soreness, Vaginal irritation/itching, Dyspareunia)] 4. Having an indication and agree to receive micro-ablative fractional vaginal CO2 Laser treatment after comprehensive counseling by their attending doctors. These are indications for Vaginal CO2 Laser therapy. 1. Patients with contraindications to hormonal use include those with breast cancer, known ischemic heart disease, migraines with auras, endometrial cancer, cirrhosis, hepatocellular adenoma, or malignant hepatoma. 2. Patients dissatisfied with local hormonal therapy.
Exclusion criteria
Exclusion criteria: 1. Participants who have undergone vaginal laser therapy within 6 months 2. Using oral hormonal therapy within 2 months. 3. Using products with Lactobacillus content within the past 2 months such as Vaginal probiotic, Yogurt 4. Using of antibiotics or anti-fungal, orally, or vaginally, within the past 2 weeks. 5. Using local hormonal therapy within 2 weeks. 6. Having vaginal intercourse within the past 48 hours. 7. Using vaginal douches, lubricants within the past 48 hours. 8. Current or history of any systemic immunosuppressive conditions or diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assess changes in prevalence vaginal Lactobacillus count (Immediate, 3 months, 6 months) after complete vaginal laser therapy Gram stains technique | — |
Secondary
| Measure | Time frame |
|---|---|
| Assess changes in prevalence vaginal Lactobacillus count (Immediate, 3 months, 6 months) after complete vaginal laser therapy expanded quantitative culture (EQC),Examine the relationship between vaginal Lactobacillus prevalence alteration and improvements in vulvovaginal atrophy symptom severity (Immediate, 3 months, 6 months) after complete vaginal laser therapy Using a questionnaire interview,assess sustained vaginal symptom relief after three and six months of treatment (3 months, 6 months) after complete vaginal laser therapy Using a questionnaire interview | — |
Countries
Thailand
Contacts
Public ContactTeerapan Seehanantawong
Faculty of Medicine, Ramathibodi Hospital, Mahidol Unversity
Outcome results
None listed