Randomized Double-Blind comparative study between topical sucralfate and nitroglycerine in the treatment of chronic or subacute anal fissure

Status

Unknown

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20240525002

Enrollment

Registered

2024-05-25

Start date

2023-10-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic anal fissure subacute anal fissure Fissure in Ano chronic subacute

Interventions

3% sucralfate apply bid,0.2% nitroglycerine apply bid

Experimental Drug,Active Comparator Drug

topical sucralfate,topical nitroglycerine

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Adult >18 years old 2. subacute or chronic anal fissure 3. patient had symptoms of anal fissure

Exclusion criteria

Exclusion criteria: 1. acute anal fissure 2. fissure from Crohn's disease, immunocompromised status, tuberculosis or anal cancer 3. pregnancy or lactation 4. allergy to component of topical sucralfate cream 5. contraindication to nitrate treatment

Design outcomes

Primary

Measure	Time frame
healing 2-4 weeks direct observation	—

Secondary

Measure	Time frame
quality of life 2 weeks HEMO-FISS-QoL questionnaire	—

Countries

Thailand

Contacts

Public ContactPornraksa Ovartchaiyapong

Faculty of Medicine, Siriraj Hospital

quantu_p@hotmail.com024198005

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026