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Efficacy of Aloe vera toothpaste during active periodontal treatment: A clinical study

Efficacy of Aloe vera toothpaste during active periodontal treatment: A clinical study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
TCTR
Registry ID
TCTR20240516001
Enrollment
90
Registered
2024-05-16
Start date
2021-03-03
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

While professional dental treatments are mandatory for advance periodontitis, maintaining proper oral hygiene can significantly contribute to preventing disease progression. Some herbal toothpastes and natural plant components may have some beneficial properties. . A toothpaste containing salt and Aloe vera may have adjunctive influence to non-surgical periodontal treatment. Aloe vera, Herbal product, Toothpaste, Periodontitis, Periodontal treatment

Interventions

herbal toothpaste containing the following active ingredients: A. vera, sodium chloride, mangosteen peel, whole Hydrocotyle plant, Clinacanthus nutans, extracts of orange jessamine leaf and toothbrush
Aloe vera toothpaste (test group),Sodium bicarbonate toothpaste (control group),Base toothpaste (benchmark group)

Sponsors

the National Science and Technology Development Agency under the Ministry of Science and Technology, Thailand.
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 70 Years

Inclusion criteria

Inclusion criteria: The subjects were required to 1. Have at least 4 permanent teeth with periodontal pocket depth greater than 4 mm along with radiographic alveolar bone destruction 2. Have full mouth plaque score more than 40 percent 3. Exhibit bleeding on probing more than 30 percent 4. Be in the age range of 20 to 70 years 5. Provide informed consent

Exclusion criteria

Exclusion criteria: The participants who 1. Had been diagnosed as dental plaque induced gingivitis or nonplaque induced gingival lesions 2. Had nonsurgical periodontal treatment in the preceding 12 months, 3. Had orthodontic treatment within 12 weeks 4. Had periodontal surgery in the preceding 12 weeks 5. Had ongoing treatment with antimicrobials and/or anti-inflammatory medication 6. Had been pregnancy or lactation 7. Had been smoking or alcohol abuse 8. Had a history of an allergic reaction to the toothpastes

Design outcomes

Primary

MeasureTime frame
gingival inflammation 3 months bleeding gon probing

Secondary

MeasureTime frame
probing depth reduction 3 months probing depth

Countries

Thailand

Contacts

Public ContactPapatpong Sirikururat

Rangsit university

papatpong.s@rsu.ac.th66813714151

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026