a novel adjunctive approach for identifying dysplastic alterations in oral epithelial tissue. Oral cancer
Conditions
Interventions
Apply electrospun containing toluidine blue for detection of oral potentially malignant disorders
compare with biopsy for histopathologic evaluation
Experimental Device
Electrospun containing Toluidine Blue
Sponsors
Royal College of Dental Surgeons of Thailand
Eligibility
Sex/Gender
All
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Male or female, age > 20 years old 2. Patients who are suspected of having oral potentially malignant disorders 3. Patients with non-healing ulcer > 2 weeks 4. Patients who can be followed up 5. Patients who give their consent for the study
Exclusion criteria
Exclusion criteria: 1. Patients with severe systemic diseases 2. Patients having obvious invasive carcinomas 3. Patients who abandoned treatment 4. Patients who refuse to join the study 5. Patients who are allergic to toluidine blue, acetic acid, polyvinylpyrrolidone or local anesthetic agents 6. Patients who deny tissue biopsy with toluidine blue
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity 3 months after intervention Compare with pathologic evaluation,Specificity 3 months after intervention Compare with pathologic evaluation | — |
Secondary
| Measure | Time frame |
|---|---|
| Sex after end of the intervention using a questionnaire interview,Age after end of the intervention using a questionnaire interview,Location of lesion after end of the intervention using clinical evaluation,Habit after end of the intervention using a questionnaire interview | — |
Countries
Thailand
Contacts
Public ContactSupanat Supakornpichan
Faculty of Dentistry, Chiang Mai University
Outcome results
None listed