Skip to content

Effectiveness of intravenous dexamethasone plus adductor canal block vs adductor canal block alone to prolong analgesia following total knee arthroplasty: A randomized controlled trial

Effectiveness of intravenous dexamethasone plus adductor canal block vs adductor canal block alone to prolong analgesia following total knee arthroplasty: A randomized controlled trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20240428001
Enrollment
64
Registered
2024-04-28
Start date
2024-05-02
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing elective unilateral TKA OA knee TKA Adductor canal block Pain score Morphine consumption

Interventions

Participants received 10 mg IV dexamethasone(2.5 ml) with ultrasound-guided ACB using 0.25% bupivacaine 20 ml before spinal anesthesia,Participants received normal saline 2.5 ml IV with ultrasound
Experimental Drug,Placebo Comparator Drug
intravenous dexamethasone,normal saline 2.5 ml

Sponsors

Rayong Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
55 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Aged 55-80 years with ASA class of I-III scheduled to undergo primary unilateral elective TKA 2.Gave informed consent to participate 3.non DM patient 4.body mass index of 18 -40 kg/m2

Exclusion criteria

Exclusion criteria: 1.Cognitive functional impairment 2.Contraindication for neuraxial anesthesia and peripheral anesthesia 3.Severe kidney or liver disease 4.Allergic to or contraindication for any of the study drugs 5.Chronic opioid use 6.Receive systemic steroid within 3 months before surgery

Design outcomes

Primary

MeasureTime frame
TIme to first analgesic request Postoperative period Hour

Secondary

MeasureTime frame
Paine score 6,12,18,24 hour postoperation Visual analogue scale,Morphine consumption first 24 hours postoperatively mg

Countries

Thailand

Contacts

Public ContactSumaporn Bunyalesniruntr

Rayong Hospital

saimione@hotmail.com0892571510

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026