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The Effect of Date Syrup, Allulose, and Other Natural Sweeteners on Oral Health

The Acidogenic Potential of Date Syrup and Allulose in the Human Oral Cavity: A Crossover Randomized Clinical Trial

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
TCTR
Registry ID
TCTR20240427015
Enrollment
10
Registered
2024-04-27
Start date
2023-11-06
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Caries Oral Health Dental Caries Oral Health Sweeteners

Interventions

Ten experiments were arranged for each participant and were executed in a randomized sequence. The trials involved the consumption of 15mL of various sweeteners (date syrup, maple syrup, allulose, and
Experimental Dietary Supplement,Active Comparator Dietary Supplement,Experimental Dietary Supplement,Active Comparator Dietary Supplement,Experimental Dietary Supplement,Active Comparator Dietary Supp
Date Syrup ,Date Syrup + pancake,Maple Syrup,Maple Syrup + pancake,Allulose Syrup,Allulose Syrup + pancake,Honey,Honey + pancake,10% sucrose,10% xylitol

Sponsors

None listed

Eligibility

Sex/Gender
All
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Healthy adults who: 1 do not smoke 2 do not suffer any significant oral, dental, or systemic diseases

Exclusion criteria

Exclusion criteria: 1 presence of active dental caries 2 food allergies 3 acid reflux disease 4 currently undergoing orthodontic treatment 5 intra-oral appliance usage 6 usage of drugs that induces dry-mouth 7 recent antibiotics use (within 3 months) 8 Simplified Oral Hygiene Index (OHI-S) score above 1.2.

Design outcomes

Primary

MeasureTime frame
Salivary pH This was done for the saliva samples collected at baseline and after 5, 10, 15, 30, and 60 minutes of the intervention. Salivary pH is measured using a calibrated pH meter (Thermo Scientific Orion Star A211 Benchtop pH Meter, Catalog No. STARA2110).

Secondary

MeasureTime frame
Salivary flow rate This was done for the saliva samples collected at baseline and after 5, 10, 15, 30, and 60 minutes of the intervention. The samples were weighed using a digital scale, and the weightwas divided by the duration of collection, yielding the salivary flow rate in (g/min), which is roughly equivalent to the (mL/min) value.

Countries

United Arab Emirates

Contacts

Public ContactAbdulrahman Salmeh

Univeristy of Sharjah

u18104966@sharjah.ac.ae971565522657

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026