A Comparative Study of the Effects of Different Types of Eyelid Cleansers on the Ocular Surface Microbiota and Disease Activity in Patients with Mild to Moderate Meibomian Gland Dysfunction: A Randomized Controlled Trial

A Comparative Study of the Effects of Different Types of Eyelid Cleansers on the Ocular Surface Microbiota and Disease Activity in Patients with Mild to Moderate Meibomian Gland Dysfunction: A Pilot Randomized Controlled Trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20240426005

Enrollment

128

Registered

2024-04-26

Start date

2025-03-06

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild to Moderate Meibomian Gland Dysfunction Microbiota Meibomian Gland Dysfunction Eyelid Cleansers

Interventions

Ocusoft lid cleanser foam and patch,Johnson and Johnson baby shampoo

Experimental Other,Active Comparator Other

Ocusoft lid cleanser,Baby Shampoo

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age >18 years old 2. Patient with mild to moderate MGD

Exclusion criteria

Exclusion criteria: 1. Vernal or atopic keratoconjunctivitis 2. Rosacea 3. Altered eyelid anatomy, pterygium or trichiasis 4. Active ocular surface diseases other than mild to moderate MGD, such as keratitis and anterior blepharitis 5. Active orbital/ocular adnexal diseases such as dacryocystitis, nasolacrimal duct obstruction and thyroid eye disease. 6. Previous punctual occlusion or ocular/ocular adnexal surgery 7. History of ocular and adnexal injuries within 1 year 8. Contact lens use within six months 9. Anti-glaucoma, antibiotics, steroids, and cyclosporin or other immunosuppressive drugs within a month 10. Diabetes mellitus 11. Autoimmune diseases 12. Immunocompromised conditions such as human immunodeficiency virus infection and cancer on chemotherapy 13. Pregnancy or lactation 14. History of allergy to the components of shampoo and lid cleansing agents

Design outcomes

Primary

Measure	Time frame
To compare the profiles of ocular surface microbiota before and after treatment with lid cleansers 1 month DNA	—

Secondary

Measure	Time frame
To compare the profiles of ocular surface microbiota after treatment between patients with mild to moderate MGD 1 month DNA,To compare the clinical score of MGD before and after treatment with lid cleansers in patients with mild to moderate MGD 1 month DNA,To compare the clinical score of after treatment with lid cleansers between patients with mild to moderate MGD 1 month DNA,To explore the association between diversity/abundance of microbiota and severity of MGD 1 month DNA	—

Measure

Time frame

To compare the profiles of ocular surface microbiota after treatment between patients with mild to moderate MGD 1 month DNA,To compare the clinical score of MGD before and after treatment with lid cleansers in patients with mild to moderate MGD 1 month DNA,To compare the clinical score of after treatment with lid cleansers between patients with mild to moderate MGD 1 month DNA,To explore the association between diversity/abundance of microbiota and severity of MGD 1 month DNA

—

Countries

Thailand

Contacts

Public ContactPhit Upaphong

Faculty of Medicine ,Chiang Mai University

phit.u@cmu.ac.th0835153538

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026