Protein bound uremic toxins removal in chronic hemodialysis Small, middle and large molecular weight uremic toxins removal in chronic hemodialysis patients Super High-flux dialyzers Medium cut-off membrane Online hemodiafiltration Indoxyl sulfate Dialysate albumin loss
Conditions
Interventions
Chronic hemodialysis patients use super-high flux dialyzer with hemodialysis for 8 weeks.,Chronic hemodialysis patients use super-high flux dialyzer with pre-dilution online hemodiafiltration for 8 we
Experimental Other,Experimental Other
SHF-HDF,SHF-HD
Sponsors
Faculty of Medicine, Chulalongkorn University
Eligibility
Sex/Gender
All
Age
18 Days to 90 Years
Inclusion criteria
Inclusion criteria: Hemodialysis patients with dialysis vintage at King Chulalongkorn Memorial hospital for more than 3 months Adequate hemodialysis by Kt/V as the recommended guideline Urine output less than 100 ml/day Stable hemodynamic for at least 2 weeks before entering the research
Exclusion criteria
Exclusion criteria: Active cardiovascular disease, active severe infection Severe dialyzer allergy Malnutrition requiring intradialytic parenteral nutrition Cirrhosis child C or decompensated cirrhosis Advance stage malignancy Have a chance to get living related kidney transplant within 1 year Unwilling to participate the project
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Free and total indoxyl sulfate reduction ratio at 8 weeks after the end of each intervention Percent | — |
Secondary
| Measure | Time frame |
|---|---|
| Kappa and lambda free light chain reduction ratio at 8 weeks after the end of each intervention Percent,Beta-2 microglobulin reduction ratio at 8 weeks after the end of each intervention Percent,Urea reduction ratio at 8 weeks after the end of each intervention Percent,Dialysate albumin loss at 1st and 8th weeks of the intervention gram per session | — |
Countries
Thailand
Contacts
Public ContactRossanun Shoosanglertwijit
Faculty of Medicine, Chulalongkorn university
Outcome results
None listed