Pilot study of thiamin deficiency and associated factors in children with transfusion-dependent thalassemia and its effect on oxidative stress

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20240416010

Enrollment

Registered

2024-04-16

Start date

2024-11-06

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thiamin deficiency, its associated factors, and its effect on oxidative stress in children with transfusion-dependent thalassemia Thiamin deficiency, children, transfusion-dependent thalassemia, oxidative stress

Interventions

Pediatric patients with Transfusion-dependent thalassemia, confirmed by hemoglobin typing

Screening

Thalassemic patients

Eligibility

Sex/Gender

All

Age

7 Years to 18 Years

Inclusion criteria

Inclusion criteria: 1. Aged 7 years to less than 18 years 2. Diagnosed as transfusion-dependent thalassemia 3. Receive regular blood transfusion for at least 12 months or 10-17 times 4. Understand Thai language 5. Eligible to give information on food frequency questionnaire and record food diary

Exclusion criteria

Exclusion criteria: 1. Underwent bariatric surgery, or had short bowel syndrome 2. Consume probiotics containing Bifidobacteria, Lactococcus, Leuconostoc, Lactobacillus sanfranciscensis, Lactobacillus rhamnosus strain GG that can synthesize thiamin 3. Receive diuretic drugs from other conditions 4. Post a critical illness within 1 month 5. Chronic infection, or recent infection within 2 weeks 6. Other hematologic disease

Design outcomes

Primary

Measure	Time frame
Proprotion of thiamin deficiency At baseline Microassay for thiamin pyrophosphate effect	—

Secondary

Measure	Time frame
associated factors of thiamin deficiecny at baseline Patient reported outcome using a questionnaire interview and food diary,oxidative stress at baseline malondialdehyde measurement,antioxidant at baseline total antioxidant capacity measurement,whole blood thiamin pyrophosphat (TPP)e level at baseline high performance liquid chromatography,growth status at baseline weight, height measurement and z-score calculation,Sample size for a prevalence study of thiamin deficiency At the end of this study Sample size for a prevalence study using a calculation equation with a proportion value	—

Measure

Time frame

associated factors of thiamin deficiecny at baseline Patient reported outcome using a questionnaire interview and food diary,oxidative stress at baseline malondialdehyde measurement,antioxidant at baseline total antioxidant capacity measurement,whole blood thiamin pyrophosphat (TPP)e level at baseline high performance liquid chromatography,growth status at baseline weight, height measurement and z-score calculation,Sample size for a prevalence study of thiamin deficiency At the end of this study Sample size for a prevalence study using a calculation equation with a proportion value

—

Countries

Thailand

Contacts

Public ContactNarumon Densupsoontorn

Faculty of Medicine Siriraj Hospital, Mahidol University

narumon.den@mahidol.ac.th024195947

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026