This study will be helpful in managing patients with complicated parapneumonic effusion by early intervention with instillation of intrapleural streptokinase. Intrapleural streptokinase, complicated pleural effusion, children
Conditions
Interventions
50ml of 0.9% normal saline will be given intrapleural. The 1st dose will be given as soon as the diagnosis of stage II complicated parapneumonic effusion is made. After washing, the chest drain will b
Placebo Comparator Drug,Active Comparator Drug
Intrapleural 0.9% Normal Saline ,Intrapleural Streptokinase
Sponsors
The Children's Hospital Lahore & University of Child Health Sciences Lahore
Eligibility
Sex/Gender
All
Age
6 Months to 15 Years
Inclusion criteria
Inclusion criteria: All children presented with stage II complicated pleural effusion/ empyema with age range of 6 months to 15 years, that fails to resolve by simple drainage by chest tube thoracotomy over 24 hours of admission.
Exclusion criteria
Exclusion criteria: Children having 1. Disseminated intravascular coagulation. 2. Volume overload. 3. Allergic/ hypersensitivity to streptokinase 4. Consent withdrawal.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Need of surgical intervention for complicated pleural effusion 6 months Chi square test | — |
Secondary
| Measure | Time frame |
|---|---|
| length of stay in the hospital 6 months chi square test | — |
Countries
Pakistan
Contacts
Public ContactSamreen Ashraf
The Children Hospital & University of Child Health Sciences
Outcome results
None listed