1. To investigate the association of early systolic blood pressure (within the first 48 hours) in sepsis without septic shock patients with SA-AKI and renal outcome 2. To determine the optimal early blood pressure that associated with the best renal outcome and mortality Acute kidney injury, Sepsis, Non-critically ill, Blood pressure
Conditions
Interventions
The mean of every 8-hour blood pressure to represent early BP within 48 hours,The mean of every 8-hour blood pressure to represent early BP within 48 hours,The mean of every 8-hour blood pressure to r
Lesser equal to 100 mmHg,101-120 mmHg,121-140 mmHg,Greater than 140 mmHg
Sponsors
Faculty of Medicine, Chiang Mai University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patient more than 18 years old, admitted in non-ICU ward 2. Meet the criteria of sepsis according to The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) including suspected or documented infection and an acute increase of greater equal to 2 SOFA points. 3. Meet the criteria of AKI according to KDIGO definition based on serum Cr measurement 4. Both criteria for sepsis and AKI were presented simultaneously within 48 hours after admission
Exclusion criteria
Exclusion criteria: 1. Critically ill patient defined as septic shock according to Sepsis-3, ICU admission, need for mechanical ventilation at the first 48 hour of admission 2. End stage renal disease or chronic kidney disease stage 5 3. Lack of baseline Cr within 1 year before diagnosis of AKI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite of long-term renal replacement therapy, a decrease of at least 25% in eGFR within 1 year after diagnosis of AKI, and 1-year mortality 1 year hemodialysis status, serum creatinine at 1 year, overall survival | — |
Secondary
| Measure | Time frame |
|---|---|
| Long term renal replacement therapy 1 year hemodialysis status,Decrease of at least 25% of eGFR within 1 year after diagnosis of AKI 1 year serum creatinine at 1 year,1-year mortality 1 year overall survival,30-day mortality 30 days overall survival,Initiate renal replacement therapy 1 year Hemodialysis status,Recurrent AKI 1 year serum creatinine within 1 year ,Readmission 1 year admission record | — |
Countries
Thailand
Contacts
Public ContactTeerawat Sriwalosakul
Faculty of Medicine, Chiang Mai University
Outcome results
None listed