Efficacy of Nalbuphine Versus Pethidine in Oocyte retrieval Nalbuphine,Pethidine,Midazolam,Oocyte retrieval, pain, sedation
Conditions
Interventions
Administer 10 mg of Nalbuphine intravenously with Midazolam 5 mg IV 10 minutes before start Oocyte retrieval procedure, record pain score, patient cooperation score, vital signs, side effects.,Adminis
Experimental Drug,Active Comparator Drug
Nalbuphine,Pethidine
Sponsors
Faculty of Medicine, Chulalongkorn University
Eligibility
Sex/Gender
Female
Age
18 Years to 48 Years
Inclusion criteria
Inclusion criteria: 1. Female age 18 to 48 years 2. Wants to undergo oocyte retrieval process for ARTs such as IVF/ICSI or social freezing
Exclusion criteria
Exclusion criteria: 1. Active liver disease or uncontrolled asthma 2. Allergic to Nalbuphine, Pethidine, Midazolam 3. Less than 3 follicles on ultrasound 4. History of Monoamine oxidase inhibitors (MAOIs) or Tricyclic antidepressant use in 2 weeks before the procedure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score postoperation at 0 hr Visual analogue scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects within 24 hours after intervention Patient reported using a questionnaire interview,Patient cooperation score during the procedure Operator reported using a questionnaire interview,Quality of egg retrieved after the oocyte retrieval percent of MII egg retrieved. counted by experienced medical lab personnel ,Pain score 2,6 hr postoperation at 2, 6 hr VAS, Vital signs After 10 min of injection and post-operation at 0,30,60 min BP, HR, SpO2, RR using NIBP, Pulse oximeter,Rescue drug needed Intra-operation, Post operation until 24 hr Report by medical personnel, patient (at home) | — |
Countries
Thailand
Contacts
Public ContactPitchapa Emeam
Faculty of Medicine, Chulalongkorn University
Outcome results
None listed