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Dynamic arterial elastance for predicting mean arterial pressure response to fluid administration in hypotensive critically ill surgical patients : Prospective observational study

Dynamic arterial elastance for predicting mean arterial pressure response to fluid administration in hypotensive critically ill surgical patients : Prospective observationalstudy

Status
Unknown
Phases
Unknown
Study type
Observational
Source
TCTR
Registry ID
TCTR20240330001
Enrollment
73
Registered
2024-03-30
Start date
2024-04-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative hypotension Dynamic arterial elastance ,Postoperative hypotension, Mean arterial pressure response

Interventions

When patient develop postoperative hypotension with 24-48 hours after surgery, they can be initially resuscitated with norepinephrine dose less or equal to 0.05 mcg/kg/min. Consider use pulse pressur
Diagnostic
Postoperative hypotension

Sponsors

Ratchadapisek Research Funds Type I (Faculty of Medicine Chulalongkorn university)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Age 18 years or older 2. High risk surgical patient (as definition of 2022 The European Society of Cardiology Guidelines on cardiovascular assessment and management of patients undergoing non-cardiac surgery) 3. Postoperative hypotension : defined as MAP less than or equal to 65 mmHg (patient may receive prior resuscitation with norepinephrine dose less than or equal to 0.05 mcg/kg/min) 4. Controlled mechanical ventilation (TV greater than or equal to 8 cc/kg ) 5. Positive Fluid responsiveness define as pulse pressure variation (PPV) greater than or equal to 12%

Exclusion criteria

Exclusion criteria: 1. Cardiac arrhythmia 2. Ratio of heart rate (HR) to respiratory rate (RR) < 3.6 3. HR < 60 4. Patient underwent cardiothoracic surgery 5. Increase intraabdominal pressure 6. Acute respiratory distress syndrome (ARDS) 7. Right heart failure 8. Valvular heart disease 9. Significant myocardial disease 10. Pulmonary edema 11. Pregnancy 12. Peripheral arterial disease (PAD)

Design outcomes

Primary

MeasureTime frame
Primary outcome 0,1,2,3,4,5 min Determine ability of Eadyn for predicting MAP responsiveness after fluid administration of post operative hypotension in critically ill surgical patients.—

Secondary

MeasureTime frame
Secondary outcome after fluid administration Compare ability of Eadyn, SVR, DSI for predicting MAP responsiveness after fluid administration.,Secondary outcome after fluid administration Total amount of fluid resuscitation in postoperative hypotension patient that receive Eadyn monitoring—

Countries

Thailand

Contacts

Public ContactDepartment of Anesthesiology King Chulalongkorn Memorial Hospital

Faculty of Medicine, Chulalongkorn University

isaravadee.r@chula.ac.th022564000

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026