The modulation of gut microbiota, metabolites, and short-chain fatty acids in obese Thai children while receiving synbiotics. obesity, synbiotic, prebiotic, probiotic, short chain fatty acids, metabolites, gut microbiota
Conditions
Interventions
The synbiotic product consists of a combination of prebiotics and probiotics. The prebiotic component comprises of inulin, while the probiotics include Bifidobacterium longum B69, Bifidobacterium adol
Experimental Other,Placebo Comparator Other
Synbiotic,Placebo
Sponsors
Faculty of Medicine, Chulalongkorn University
Eligibility
Sex/Gender
All
Age
7 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Age 7 to 18 years 2. BMI > median + 2SDs (WHO reference) 3. No history of pre-/pro-/ synbiotic supplementation or antibiotics use at least 4 weeks prior to participation.
Exclusion criteria
Exclusion criteria: 1. Cow's milk protein allergy 2. Syndromic obesity 3. Endocrine causes of obesity (e.g. hypothyroidism, growth hormone deficiency) 4. Use of drugs that influence apetite or body weight (e.g. corticosteroids) 5. Attending other concurrent weight reduction programs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Short chain fatty acids At the time of enrollment and three months thereafter Measure in stool sample,Gut microbiota At the time of enrollment and three months thereafter Measure in stool sample | — |
Secondary
| Measure | Time frame |
|---|---|
| Metabolites profile At the time of enrollment and three months thereafter Measure in serum: iNOS, IL-1B, MCP-1, LPS, LBP, MDA, TGF-B, FIZZ, Arginase, IL-10 ,Metabolic profiles At the time of enrollment and three months thereafter Measure in serum lipid profile, fasting blood sugar levels, and insulin levels | — |
Countries
Thailand
Contacts
Public ContactChonnikant Visuthranukul
Faculty of Medicine, Chulalongkorn University
Outcome results
None listed