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Assessment of Ventriculo-arterial Coupling Characteristics in Sepsis Patients Undergoing Fluid Resuscitation Through Stroke Volume and Calculated End-systolic Pressure interaction

Assessment of Ventriculo-arterial Coupling Characteristics in Sepsis Patients Undergoing Fluid Resuscitation Through Stroke Volume and Calculated End-systolic Pressure interaction

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
TCTR
Registry ID
TCTR20240320006
Enrollment
100
Registered
2024-03-20
Start date
2023-12-13
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with septic shock undergo fluid bolus Ventriculo-arterial Coupling, Arterial Elastance, End-systolic pressure, stroke volume, Septic shock, Fluid resuscitation, Atrial fibrillation

Interventions

The initial study, conducted in 2012, employed the diagnostic criteria for sepsis or septic shock as defined by the International Sepsis Definitions Conference. The primary objective of this research
Basic Science
Septic shock patients from 3 prior studies

Sponsors

None listed

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: aged 18 years and older who presented with newly developed sepsis and were transferred to the MICU following participation in three prior prospective studies

Exclusion criteria

Exclusion criteria: pregnancy, increased intra-abdominal pressure, deep venous thrombosis, significant intra-abdominal masses, pulmonary edema, cardiac failure, brain edema, contraindications for arterial catheter placement, and contraindications for pulse contour cardiac output monitoring

Design outcomes

Primary

MeasureTime frame
Pes-SV interaction 1 h after intervention Percentage of number of patients who had change in Pes and SV after fluid bolus

Secondary

MeasureTime frame
subgroups 1 h after intervention Percentage of number of patients who had change in Pes and SV after fluid bolus

Countries

Thailand

Contacts

Public ContactIssara Boonyarangkul

Faculty of Medicine Ramathibodi Hospital

Boon.issara@gmail.com022011619

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026