colon cancer oxaliplatin hypersensitivity reaction colon cancer oxaliplatin hypersensitivity reaction high dose dexamethasone
Conditions
Interventions
1. Chemotherapy Nurse Initiates IV Access and Starts Hydration
Starts a peripheral IV line with 1,000 mL of D5W at a rate of 40 mL per hour.
2. Chemotherapy Nurse Administers Premedication
Administer
Active Comparator Drug,Active Comparator Drug
dexamethasone 20 mg,dexamethasone 12 mg
Sponsors
Sisaket Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with cancer, aged at least 18 years, diagnosed with colorectal cancer who have received oxaliplatin 2. In the case of metastatic disease, participants must not have received oxaliplatin before 3. In the case of adjuvant oxaliplatin treatment, it must be stopped at least 6 months before entering the study 4. ECOG performance status 0-2 4. Life expectancymmore than 12 weeks 5. Blood test results: ANC more than 1,000/mm3, platelet more than 75,000, Hb more than 8 g/dL, total bilirubin more than 2, Cr less than 1.5 times the upper normal limit 6. Patients who have signed informed consent to participate in the research project
Exclusion criteria
Exclusion criteria: 1. Patients with a history of severe allergic reactions to oxaliplatin or other platinum-containing compounds 2. Patients with severe hypersensitivity to other drugs or excipients in the study drug 3. Patients with uncontrolled underlying diseases 4. Patients with multiple primary cancers in the past 5 years 5. Patients with pleural effusion, pericardial effusion, or ascites that require drainage 6. Patients with significant mental or psychological illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| events of oxaliplatin hypersensitivity reaction occurs for each arm after all subjects compelete chemotherapy protocol the presence or absence of allergic reactions to oxaliplatin | — |
Secondary
| Measure | Time frame |
|---|---|
| exacerbation of diabetes after all subjects compelete chemotherapy protocol fasting plasma glucose,osteoporosis after all subjects compelete chemotherapy protocol bone mineral density (BMD),Compression fracture after all subjects complete chemotherapy protocol film X-ray spine,Edema after all subjects complete chemotherapy protocol pitting edema grading scale | — |
Countries
Thailand
Contacts
Public ContactChatsuda Sookthon
Si Sa Ket Hospital
Outcome results
None listed