Chronic rhinosinusitis Chronic rhinosinusitis Eosinophilic chronic rhinosinusitis Non-eosinophilic chronic rhinosinusitis Tissue eosinophil Extent of Sinus surgery sinus surgery Symptoms VAS SNOT-22 Lund -Kennedy endoscopy score Lund-Mackay CT scan score Kennedy osteitis score Blood eosinophil Allergic rhinitis Asthma NSAID-exacerbated respiratory disease ECRS NECRS CRS ESS extent of ESS impact of extent of ESS
Conditions
Interventions
Observe the association between the number of tissue eosinophil and clinical characteristics of CRS patients,Observe the association between extent of sinus surgery and therapeutic outcomes
Diagnostic,Diagnostic
Tissue eosinophil group,Extent of sinus surgery group
Sponsors
Ratchadapisek Research Funds, Faculty of Medicine, Chulalongkorn University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age above 18 years 2. Chronic rhinosinusitis following diagnostic criteria of EPOS2020 3. Failed to improve from a minimum of 6-week period medical therapy requiring ESS 4. All patients underwent ESS 5. Able to give informed consent
Exclusion criteria
Exclusion criteria: - Unilateral sinus disease: fungal ball, odontogenic-related disease, allergic fungal sinusitis, neoplasm associated with sinus disease - Systematic disease associated with sinus: cystic fibrosis, Churg-Strauss, immunodeficiency, Wegener granulomatosis, autoimmune disease - Undertaking immunosuppressive medicines - Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SNOT-22 1 year linear regression | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS symptoms, LK score, LM CT score, Kennedy osteitis score, Blood eosinophil count, Comorbidities: Allergic rhinitis, Asthma, NSAID-exacerbated respiratory disease (NERD) 1 year spearman rank order coefficient, logistic regression , | — |
Countries
Thailand
Contacts
Public ContactJompol Samuthpongtorn
Faculty of Medicine, Chulalongkorn University
Outcome results
None listed