EPILEPSY DRUGS EPILEPSY DRUGS
Conditions
Interventions
after group allotment in group a will give initial dose of midazolam 0.2 mg per kg up to 10 mg. we will start midazolam infusion at 1 mcg per kg per minute and increase by 1 mcg per minute every 5 m
Experimental Drug
efficacy of midazolam and sodium valproate
Sponsors
University of Health Sciences Lahore,pakistan
Eligibility
Sex/Gender
All
Age
2 Years to 14 Years
Inclusion criteria
Inclusion criteria: All children presenting with status epilepticus with duration > 5 minutes. Failure of first and second line antiepileptics age group 2 to 14 years
Exclusion criteria
Exclusion criteria: All children with diagnosed muscular dystrophies on clinical examination. severe hypotension(according to age ) severe atrial or ventricular block(on ecg) metabolic diseases (hypoglycemia, hypocalcemia, hypomagnesemia, hyponatremia, hypenatremia, uremicencephalophaty, hepaticencephlopathy). History of use of anticonvulsants before presenting to hospital. Renal or Hepatic diseases on medical records and relevant investigations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy 24 hours It will be determined in terms of complete cessation of seizures within 30 minutes of initiation of therapy and absence of seizure recurrence after completing the last dose of anticonvulsant. | — |
Secondary
| Measure | Time frame |
|---|---|
| NA NA NA | — |
Countries
Pakistan
Contacts
Public Contactshahid latif
University of Health Sciences Lahore
Outcome results
None listed